Shimizu Shogo, Tsounapi Panagiota, Shimizu Takahiro, Honda Masashi, Inoue Keiji, Dimitriadis Fotios, Saito Motoaki
Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Japan.
Int J Urol. 2014 Sep;21(9):856-64. doi: 10.1111/iju.12501. Epub 2014 Jun 15.
Although the pathogenesis of lower urinary tract symptoms, benign prostatic hyperplasia/benign prostatic enlargement and erectile dysfunction is poorly understood and thought to be multifactorial, it has been traditionally recognized that these conditions increase with age. There is increasing evidence that there is an association between cardiovascular disease and lower urinary tract symptoms as well as benign prostatic hyperplasia/benign prostatic enlargement and erectile dysfunction in elderly patients. Age might activate systemic vascular risk factors, resulting in disturbed blood flow. Hypertension, diabetes, hyperlipidemia and atherosclerosis are also linked to the etiology of lower urinary tract symptoms, benign prostatic hyperplasia/benign prostatic enlargement and erectile dysfunction. In the present review, we discuss the relationship between decreased pelvic blood flow and lower urinary tract symptoms, benign prostatic hyperplasia/benign prostatic enlargement and erectile dysfunction. Furthermore, we suggest possible common mechanisms underlining these urological conditions.
尽管下尿路症状、良性前列腺增生/前列腺肿大和勃起功能障碍的发病机制尚不清楚，且被认为是多因素的，但传统上人们已经认识到，这些病症会随着年龄的增长而增加。越来越多的证据表明，老年患者心血管疾病与下尿路症状以及良性前列腺增生/前列腺肿大和勃起功能障碍之间存在关联。年龄可能会激活全身血管危险因素，导致血流紊乱。高血压、糖尿病、高脂血症和动脉粥样硬化也与下尿路症状、良性前列腺增生/前列腺肿大和勃起功能障碍的病因有关。在本综述中，我们讨论了盆腔血流减少与下尿路症状、良性前列腺增生/前列腺肿大和勃起功能障碍之间的关系。此外，我们提出了这些泌尿系统疾病可能的共同潜在机制。
