Department of Periodontology, Dental Research Division, Guarulhos University, São Paulo, Brazil.
J Clin Periodontol. 2014 Sep;41(9):890-9. doi: 10.1111/jcpe.12282. Epub 2014 Jul 17.
To evaluate the clinical and microbiological effects of the use of metronidazole (MTZ) + amoxicillin (AMX) as adjuncts to scaling and root planing (SRP) for the treatment of chronic periodontitis (ChP) in type 2 diabetic subjects.
Fifty-eight type 2 diabetic subjects (n = 29/group) with generalized ChP were randomly assigned to receive SRP alone or with MTZ [400 mg/thrice a day (TID)]+AMX (500 mg/TID) for 14 days. Subgingival biofilm samples were analyzed by qPCR for the presence of seven periodontal pathogens. Subjects were monitored at baseline, 3, 6 and 12 months post-therapies.
The group receiving SRP+MTZ+AMX presented greater mean probing depth (PD) reduction and clinical attachment gain, a lower number of sites with PD ≥5 mm (primary outcome variable) and a reduced number of subjects with ≥9 of these residual pockets than the control group at 1-year post-therapy (p < 0.05). The antibiotic-treated group also presented reduced levels and greater decreases of the three red complex species, Eubacterium nodatum and Prevotella intermedia, compared to the control group at 1 year (p < 0.05).
The adjunctive use of MTZ+AMX significantly improved the clinical and microbiological outcomes of SRP in the treatment of type 2 diabetic subjects with ChP.
评估甲硝唑（MTZ）+阿莫西林（AMX）作为辅助治疗在 2 型糖尿病患者慢性牙周炎（ChP）中的临床和微生物学效果。
将 58 名患有广泛性 ChP 的 2 型糖尿病患者（n=29/组）随机分为单独接受牙周刮治和根面平整术（SRP）或接受 MTZ[400mg/每天 3 次（TID）]+AMX（500mg/每天 TID）治疗 14 天。采用 qPCR 分析龈下生物膜样本中七种牙周病原体的存在情况。在基线、3、6 和 12 个月时对受试者进行监测。
在治疗 1 年后，接受 SRP+MTZ+AMX 治疗的组的平均探诊深度（PD）降低更多，临床附着增加，PD≥5mm 的位点数量更少（主要观察变量），且有≥9 个这些残留袋的患者数量少于对照组（p<0.05）。与对照组相比，在治疗 1 年后，抗生素治疗组的三种红色复合体物种、真杆菌属和中间普氏菌的水平降低，减少幅度更大（p<0.05）。
MTZ+AMX 作为辅助治疗可显著改善 2 型糖尿病患者 ChP 的 SRP 的临床和微生物学结果。
