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前庭神经鞘瘤的保守治疗

Conservative management of vestibular schwannoma.

作者信息

González-Orús Álvarez-Morujo Ricardo José, Alvarez-Palacios Itziar, Martin-Oviedo Carlos, Scola-Yurrita Bartolomé, Arístegui-Ruiz Miguel Ángel

机构信息

Servicio de ORL, Hospital General Universitario Gregorio Marañón, Madrid, España.

Servicio de ORL, Hospital General Universitario Gregorio Marañón, Madrid, España.

出版信息

Acta Otorrinolaringol Esp. 2014 Sep-Oct;65(5):275-82. doi: 10.1016/j.otorri.2014.01.002. Epub 2014 Jun 13.

Abstract

INTRODUCTION

Vestibular schwannoma (VS) is a benign, slow-growing tumour originating in the 8th cranial nerve. The treatment includes microsurgery, stereotactic radiotherapy and conservative management of tumours with periodic radiological tests.

METHODS

This was a retrospective study of patients with VS following conservative management in a tertiary hospital between 1993 and 2013. A total of 73 patients were enrolled in our protocol. The mean age at diagnosis was 59.7 years. The average size was 11.9mm (4-27mm); 58.9% of the tumours were intracanalicular and 41.1%, extracanalicular. The mean follow-up period was 35.75 months.

RESULTS

In 87.7% of patients there was no evidence of tumour growth. A total of 9 tumours (12.3%) increased in size. The average growth rate was 0.62mm/year. The percentage of extracanalicular tumours that grew (20%) was higher than that of intracanalicular tumours (7%). Seven patients (9.5%) experienced significant changes in their symptoms and 6 of these (8.2%) experienced a loss of useful hearing. Six patients (8.2%) left follow-up and underwent surgery.

CONCLUSIONS

Periodic monitoring of vestibular schwannomas with magnetic resonance imaging represents an option for management, because most small tumours experience little or no growth over time.

摘要

引言

前庭神经鞘瘤(VS)是一种起源于第8颅神经的良性、生长缓慢的肿瘤。治疗方法包括显微手术、立体定向放射治疗以及通过定期影像学检查对肿瘤进行保守治疗。

方法

这是一项对1993年至2013年在一家三级医院接受保守治疗的VS患者的回顾性研究。共有73例患者纳入我们的研究方案。诊断时的平均年龄为59.7岁。平均大小为11.9毫米(4 - 27毫米);58.9%的肿瘤位于内听道内,41.1%位于内听道外。平均随访期为35.75个月。

结果

87.7%的患者没有肿瘤生长的证据。共有9个肿瘤(12.3%)增大。平均生长速率为0.62毫米/年。内听道外肿瘤生长的百分比(20%)高于内听道内肿瘤(7%)。7例患者(9.5%)症状出现显著变化,其中6例(8.2%)有用听力丧失。6例患者(8.2%)中断随访并接受了手术。

结论

通过磁共振成像定期监测前庭神经鞘瘤是一种治疗选择,因为大多数小肿瘤随着时间推移生长很少或不生长。

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