Casanova I, Diaz A, Pinto S, de Carvalho M
Clinical and translational physiology unit, physiology institute, faculty of medicine, Instituto de Medicina Molecular, university of Lisbon, avenue Professor Egas Moniz, 1649-028 Lisbon, Portugal.
Clinical and translational physiology unit, physiology institute, faculty of medicine, Instituto de Medicina Molecular, university of Lisbon, avenue Professor Egas Moniz, 1649-028 Lisbon, Portugal.
Neurophysiol Clin. 2014 Apr;44(2):213-8. doi: 10.1016/j.neucli.2014.03.002. Epub 2014 Apr 2.
The technique of threshold tracking to test axonal excitability gives information about nodal and internodal ion channel function. We aimed to investigate variability of the motor excitability measurements in healthy controls, taking into account age, gender, body mass index (BMI) and small changes in skin temperature.
We examined the left median nerve of 47 healthy controls using the automated threshold-tacking program, QTRAC. Statistical multiple regression analysis was applied to test relationship between nerve excitability measurements and subject variables.
Comparisons between genders did not find any significant difference (P>0.2 for all comparisons). Multiple regression analysis showed that motor amplitude decreases with age and temperature, stimulus-response slope decreases with age and BMI, and that accommodation half-time decrease with age and temperature.
The changes related to demographic features on TRONDE protocol parameters are small and less important than in conventional nerve conduction studies. Nonetheless, our results underscore the relevance of careful temperature control, and indicate that interpretation of stimulus-response slope and accommodation half-time should take into account age and BMI. In contrast, gender is not of major relevance to axonal threshold findings in motor nerves.
用于测试轴突兴奋性的阈值跟踪技术可提供有关结区和结间区离子通道功能的信息。我们旨在研究健康对照者运动兴奋性测量值的变异性，同时考虑年龄、性别、体重指数（BMI）以及皮肤温度的微小变化。
我们使用自动阈值跟踪程序QTRAC检查了47名健康对照者的左侧正中神经。应用统计多元回归分析来测试神经兴奋性测量值与受试者变量之间的关系。
性别之间的比较未发现任何显著差异（所有比较的P>0.2）。多元回归分析表明，运动幅度随年龄和温度降低，刺激-反应斜率随年龄和BMI降低，而适应半衰期随年龄和温度降低。
TRONDE方案参数中与人口统计学特征相关的变化较小，且比传统神经传导研究中的变化重要性更低。尽管如此，我们的结果强调了严格控制温度的重要性，并表明在解释刺激-反应斜率和适应半衰期时应考虑年龄和BMI。相比之下，性别与运动神经轴突阈值结果的相关性不大。
