肾小管基底膜电子致密沉积物的超微结构研究：患病率及其与上皮萎缩的关系。
Ultrastructural study of electron dense deposits in renal tubular basement membrane: prevalence and relationship to epithelial atrophy.
作者信息
Yong Jim L C, Killingsworth Murray C
机构信息
Department of Anatomical Pathology, Sydney South West Pathology Service (SSWPS) Liverpool , Australia .
出版信息
Ultrastruct Pathol. 2014 Aug;38(4):273-80. doi: 10.3109/01913123.2014.925021. Epub 2014 Jun 16.
This study reports the prevalence of immune deposits associated with the proximal and distal tubules in a series of routine renal biopsies received in our department during a single calendar year. From 87 cases, 65 (74%) were found to have glomerular immune deposits by immunofluorescence. Tubular immune deposits were found in 12 cases (18%), 3 of which had no glomerular deposits. By transmission electron microscopy (EM), 58 cases (66%) were found to have deposits of granular or vesicular material associated with the tubular basement membranes (TBM). Finely granular electron dense deposits appeared to correspond to the immune deposits seen by immunofluorescence microscopy (IF) and may be a sensitive marker of immune deposition.
本研究报告了在一个日历年期间我们科室接收的一系列常规肾活检中与近端和远端肾小管相关的免疫沉积物的患病率。在87例病例中，通过免疫荧光法发现65例（74%）有肾小球免疫沉积物。12例（18%）发现有肾小管免疫沉积物，其中3例无肾小球沉积物。通过透射电子显微镜（EM），发现58例（66%）有与肾小管基底膜（TBM）相关的颗粒状或泡状物质沉积物。细颗粒状电子致密沉积物似乎与免疫荧光显微镜（IF）所见的免疫沉积物相对应，可能是免疫沉积的敏感标志物。
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