肿瘤细胞对肿瘤坏死因子产生抗性并不意味着对细胞毒性药物也具有抗性。

Development of tumour cell resistance to tumour necrosis factor does not confer resistance to cytotoxic drugs.

作者信息

Neale M L, Matthews N

机构信息

Department of Medical Microbiology, University of Wales College of Medicine, Heath Park, Cardiff, U.K.

出版信息

Eur J Cancer Clin Oncol. 1989 Jan;25(1):133-7. doi: 10.1016/0277-5379(89)90061-8.

DOI:10.1016/0277-5379(89)90061-8

PMID:2493381

Abstract

Tumour necrosis factor (TNF) is a protein product of macrophages with potential anti-cancer activity. As with other anti-cancer agents, tumour cells can develop resistance to the cytotoxic effects of TNF. The aim of his study was to see whether development of resistance to TNF resulted in a concomitant resistance to other anti-cancer agents, in particular those associated with multidrug resistance. Three TNF-susceptible tumour cell lines (L929, U937 and RK13) and their TNF-resistant sublines were compared for susceptibility in vitro to several cytotoxic drugs. The TNF-resistant sublines were not significantly more resistant to these drugs. In addition, an L929 subline selected for resistance to actinomycin D retained its susceptibility to TNF. These observations show that tumour cell resistance to TNF develops independently of resistance to cytotoxic drugs.

摘要

肿瘤坏死因子（TNF）是巨噬细胞产生的一种具有潜在抗癌活性的蛋白质产物。与其他抗癌药物一样，肿瘤细胞可对TNF的细胞毒性作用产生耐药性。本研究的目的是观察对TNF耐药性的产生是否会导致对其他抗癌药物，尤其是与多药耐药相关的药物产生伴随耐药性。比较了三种对TNF敏感的肿瘤细胞系（L929、U937和RK13）及其对TNF耐药的亚系对几种细胞毒性药物的体外敏感性。对TNF耐药的亚系对这些药物的耐药性并没有显著增加。此外，一个对放线菌素D耐药的L929亚系仍对TNF敏感。这些观察结果表明，肿瘤细胞对TNF的耐药性是独立于对细胞毒性药物的耐药性而产生的。