Neale M L, Matthews N
Department of Medical Microbiology, University of Wales College of Medicine, Heath Park, Cardiff, U.K.
Eur J Cancer Clin Oncol. 1989 Jan;25(1):133-7. doi: 10.1016/0277-5379(89)90061-8.
Tumour necrosis factor (TNF) is a protein product of macrophages with potential anti-cancer activity. As with other anti-cancer agents, tumour cells can develop resistance to the cytotoxic effects of TNF. The aim of his study was to see whether development of resistance to TNF resulted in a concomitant resistance to other anti-cancer agents, in particular those associated with multidrug resistance. Three TNF-susceptible tumour cell lines (L929, U937 and RK13) and their TNF-resistant sublines were compared for susceptibility in vitro to several cytotoxic drugs. The TNF-resistant sublines were not significantly more resistant to these drugs. In addition, an L929 subline selected for resistance to actinomycin D retained its susceptibility to TNF. These observations show that tumour cell resistance to TNF develops independently of resistance to cytotoxic drugs.
肿瘤坏死因子（TNF）是巨噬细胞产生的一种具有潜在抗癌活性的蛋白质产物。与其他抗癌药物一样，肿瘤细胞可对TNF的细胞毒性作用产生耐药性。本研究的目的是观察对TNF耐药性的产生是否会导致对其他抗癌药物，尤其是与多药耐药相关的药物产生伴随耐药性。比较了三种对TNF敏感的肿瘤细胞系（L929、U937和RK13）及其对TNF耐药的亚系对几种细胞毒性药物的体外敏感性。对TNF耐药的亚系对这些药物的耐药性并没有显著增加。此外，一个对放线菌素D耐药的L929亚系仍对TNF敏感。这些观察结果表明，肿瘤细胞对TNF的耐药性是独立于对细胞毒性药物的耐药性而产生的。
