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[合并症疾病及危险因素对胃十二指肠复合性溃疡发生发展的影响]

[Influence of the comorbidity diseases and risk factors on development of the combined peptic ulcer of the stomach and the duodenum].

作者信息

Stepanishcheva L A, Sarsenbaeva A S, Fattakhova N V

出版信息

Eksp Klin Gastroenterol. 2013(8):34-40.

Abstract

RESEARCH OBJECTIVE

To define influence of the comorbidity diseases and risk factors of development of the combined peptic ulcer of a stomach and duodenum.

MATERIALS AND METHODS

As a result of carried-out poll and inspection 250 patients with an exacerbation of a peptic ulcer were surveyed. Patients were distributed in 3 groups of observation depending on localization of ulcerative process. At all surveyed questioning was carried out, data on hereditary load, smoking, alcohol intake, existence of somatopathies were specified, clinic-morphological implications of a peptic ulcer were studied.

RESULTS

The peptic ulcer of a stomach is characteristic for women (72.1%) and develops mainly aged from 45 till 59 years (60.3%). Peptic ulcer of duodenum men (76.3%) suffer mainly, the debut is the share in most cases of age from 18 to 44 years (79.1%). The combined canker of a stomach and duodenum meets at males (61.2%) more often, is initially involved in process ulcerogenesis by duodenum generally aged from 30 till 44 years (64.2%), accession of a canker of a stomach happens is delayed (at 38.8% within 16 and more years). In the analysis of risk factors at patients with the combined peptic ulcer of a stomach and duodenum depending on existence or absence specific to this category of patients of a background from such comorbidity diseases as IBS, HOBL and widespread osteochondrosis taped that larger prevalence of smoking (100%) and as the use (50%) and the excessive use (50%), alcohol are characteristic for the patients having a high comorbidity (a combination of three above nosologies).

CONCLUSION

The greatest interest in respect of possible communication with formation of the combined peptic ulcer of a stomach and duodenum is represented by IBS, HOBL and osteochondrosis. And major factors of risk were smoking, the excessive alcohol intake, the burdened heredity.

摘要

研究目的

确定合并胃十二指肠消化性溃疡的合并症疾病及发病风险因素的影响。

材料与方法

通过开展的调查和检查,对250例消化性溃疡急性发作患者进行了研究。根据溃疡病变的部位,将患者分为3组进行观察。对所有受调查者进行了询问,明确了遗传负荷、吸烟、饮酒、躯体疾病的存在情况,并研究了消化性溃疡的临床形态学特征。

结果

胃溃疡以女性(72.1%)居多,主要发病年龄在45至59岁(60.3%)。十二指肠溃疡男性患者(76.3%)居多,多数患者首次发病年龄在18至44岁(79.1%)。胃和十二指肠合并溃疡在男性中更为常见(61.2%),通常十二指肠首先发生溃疡病变,发病年龄一般在30至44岁(64.2%),胃溃疡的发生延迟(38.8%在16年及更长时间后)。在分析胃十二指肠合并消化性溃疡患者的风险因素时,根据是否存在肠易激综合征(IBS)、幽门螺杆菌感染(HOBL)和广泛性骨软骨病等此类患者特有的合并症背景,发现吸烟率较高(100%)以及饮酒(50%)和过度饮酒(50%)是高合并症患者(上述三种疾病合并)的特征。

结论

肠易激综合征、幽门螺杆菌感染和骨软骨病在胃十二指肠合并消化性溃疡形成的可能关联方面最受关注。主要风险因素为吸烟、过度饮酒和遗传负担。

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