Mazurina N V, Ogneva N A, Troshina E A, Iashkov Iu I, Mel'nichenko G A
Eksp Klin Gastroenterol. 2013(12):27-32.
Calcium metabolism in the long-term period after bariatric surgery is reviewed in the present article. The study of calcium metabolism parameters and vitamin D status was performed in The Endocrinology Research Center. Morbidly obese patients (BMI > 40) were included in the 1st group (n = 22), patients who underwent biliopancreatic diversion for morbid obesity (n = 23) were included in the 2nd group, healthy normal weight controls (n = 22) were included in the 3rd group. 25 (OH) D level was different in the 3 groups (p < 0.001). Vitamin D deficiency prevailed in morbidly obese patients compared to healthy controls (p = 0.007). Elevated parathyroid hormone (PTH) level was found in 4 (18%) morbidly obese patients, in 12 (52%) operated patients. Not a single case of PTH over reference interval was found in the controls. The frequency of secondary hyperparathyroidism was significantly higher in the operated patients.
本文综述了减肥手术后长期的钙代谢情况。在内分泌研究中心对钙代谢参数和维生素D状态进行了研究。第一组纳入病态肥胖患者(BMI>40)(n = 22),第二组纳入因病态肥胖接受胆胰转流术的患者(n = 23),第三组纳入健康体重正常的对照者(n = 22)。三组的25(OH)D水平存在差异(p<0.001)。与健康对照者相比,病态肥胖患者中维生素D缺乏更为普遍(p = 0.007)。在4例(18%)病态肥胖患者、12例(52%)接受手术的患者中发现甲状旁腺激素(PTH)水平升高。在对照组中未发现1例PTH超过参考区间的情况。接受手术的患者继发性甲状旁腺功能亢进的发生率显著更高。