Mateo María Gracia, Gutierrez María Del Mar, Vidal Francesc, Domingo Pere
Universitat Autònoma de Barcelona, Hospital de la Santa Creu i Sant Pau, Infectious Diseases Unit , Av. Sant Antoni Ma Claret, 167, 08025 Barcelona , Spain +34 935 56 56 09 ; +34 935 56 59 38 ;
Expert Opin Pharmacother. 2014 Aug;15(12):1749-60. doi: 10.1517/14656566.2014.928694. Epub 2014 Jun 16.
With the introduction of combination antiretroviral therapy (ART) for HIV infection in the mid-1990s, descriptions of morphological changes and metabolic disturbances in treated patients began to emerge. HIV-1/highly active ART-associated lipodystrophy syndrome (HALS) involves metabolic abnormalities and diverse forms of anomalous fat distribution. The current review focuses on the pathophysiological basis and the clinical evidence for the use of several medical strategies in the management of HALS.
We have covered the most relevant studies related to the pharmacological strategies in the treatment of HALS, with attention to the current and novel antiretroviral agents.
The most commonly used strategies for HALS reversion have included modification of host-dependent factors, including those related to HIV-1 infection and those associated with ART. Preventive and medical strategies have been associated with moderate success. The only intervention that offers an immediate aesthetical improvement for patients with HALS so far has been plastic surgery.
随着20世纪90年代中期抗逆转录病毒联合疗法（ART）被用于治疗HIV感染，接受治疗患者的形态学变化和代谢紊乱的相关描述开始出现。HIV-1/高效抗逆转录病毒治疗相关脂肪代谢障碍综合征（HALS）涉及代谢异常和多种形式的异常脂肪分布。本综述重点关注HALS管理中几种医学策略应用的病理生理基础和临床证据。
我们涵盖了与HALS治疗中药理学策略相关的最相关研究，重点关注当前和新型抗逆转录病毒药物。
逆转HALS最常用的策略包括改变宿主相关因素，包括与HIV-1感染相关的因素以及与抗逆转录病毒治疗相关的因素。预防和医学策略取得了一定成功。迄今为止，对HALS患者而言，唯一能立即改善美观的干预措施是整形手术。
