硼酸基酶抑制剂：近期进展综述。
Boronic acid-based enzyme inhibitors: a review of recent progress.
机构信息
Institute of Materia Medica, Shandong Academy of Medical Sciences, 18877 Jingshi Rd., Ji'nan, Shandong 250062, China.
出版信息
Curr Med Chem. 2014;21(28):3271-80. doi: 10.2174/0929867321666140601200803.
Abstract
Since Bortezomib was approved by US FDA as the first drug to treat multiple myeloma, various boronic acid compounds have been developed as enzyme inhibitors. This paper reviewed the progress of boronic acid-based inhibitors against enzymes including proteasome, serine protease, HDACs and other enzymes in the past decade.
摘要
自硼替佐米被美国食品和药物管理局批准为治疗多发性骨髓瘤的第一种药物以来，各种硼酸化合物已被开发为酶抑制剂。本文综述了过去十年中硼酸类抑制剂对蛋白酶体、丝氨酸蛋白酶、HDAC 等酶的研究进展。
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