Taşolar Hakan, Ballı Mehmet, Çetin Mustafa, Otlu Yılmaz Ömür, Altun Burak, Bayramoğlu Adil
Adiyaman University Training and Research Hospital, Department of Cardiology, Adiyaman, Turkey.
Ann Noninvasive Electrocardiol. 2015 Jan;20(1):53-61. doi: 10.1111/anec.12173. Epub 2014 Jun 16.
The clinical utility of the Tp-e interval and Tp-e/QT ratio in the risk stratification of ventricular arrhythmic events is controversial. Therefore, we investigated the impact of CCC on these electrocardiographic indexes in the course of stable CAD.
Two hundred three consecutive patients with stable CAD who underwent coronary angiography and had documented total occlusion of one of the major coronary arteries were enrolled in this prospective cross-sectional study. The Tp-e interval and Tp-e/QT ratio were measured by 12-lead electrocardiogram.
The Tp-e interval, cTp-e interval, Tp-e/QT ratio, and cTp-e/QT ratio were lower in the grade 3 CCC group compared with the others in all leads. Multivariate linear regression analyses was performed to identify the clinical factors affecting the cTp-e interval and was indicated that age (β = 0.261, P < 0.001), male sex (β = 0.334, P < 0.001), poor Rentrop grade (β = -0.228, P < 0.001), and NLR (β = 0.137, P = 0.027) were independent predictors of a prolonged cTp-e interval.
It could be concluded that the decreased dispersion of ventricular repolarization might contribute to the lower incidence of ventricular arrhythmias and SCD in CAD patients with a good CCC.
Tp-e间期和Tp-e/QT比值在室性心律失常事件危险分层中的临床应用存在争议。因此，我们研究了心肌梗死罪犯血管完全闭塞（CCC）对稳定型冠心病患者这些心电图指标的影响。
本前瞻性横断面研究纳入了203例连续的稳定型冠心病患者，这些患者接受了冠状动脉造影，且有记录显示某一支主要冠状动脉完全闭塞。通过12导联心电图测量Tp-e间期和Tp-e/QT比值。
3级CCC组所有导联的Tp-e间期、校正Tp-e间期、Tp-e/QT比值和校正Tp-e/QT比值均低于其他组。进行多因素线性回归分析以确定影响校正Tp-e间期的临床因素，结果表明年龄（β = 0.261，P < 0.001）、男性（β = 0.334，P < 0.001）、Rentrop分级差（β = -0.228，P < 0.001）和中性粒细胞与淋巴细胞比值（NLR）（β = 0.137，P = 0.027）是校正Tp-e间期延长的独立预测因素。
可以得出结论，在CCC良好的冠心病患者中，心室复极离散度降低可能导致室性心律失常和心源性猝死的发生率较低。
