Selwin Joseyphus R, Shiju C, Joseph J, Justin Dhanaraj C, Arish D
Department of Chemistry, St. John's College, Anchal, Kollam 691 306, India.
Department of Chemistry, St. John's College, Anchal, Kollam 691 306, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Dec 10;133:149-55. doi: 10.1016/j.saa.2014.05.050. Epub 2014 May 29.
The Co(II), Ni(II), Cu(II) and Zn(II) complexes of the Schiff base derived from imidazole-2-carboxaldehyde and 4-aminoantipyrine were synthesized. These compounds were characterized by elemental analysis, IR, mass, (1)H NMR, electronic spectra, magnetic moment, molar conductance, thermal analysis, powder XRD and SEM. The analytical data show that the metal to ligand ratio is 1:1. The IR results show that the ligand acts as a bidentate donor coordinating through the azomethine nitrogen and imidazole nitrogen atoms. From the electronic spectra and magnetic moment value predicts the geometry of the complexes. The surface morphology of the compounds was studied by SEM. The compounds were screened for their antibacterial activity and antifungal activity using Kirby Bayer disc diffusion method. The DNA cleavage and superoxide dismutase activities of the compounds were investigated. The anticancer activities of the complexes have been carried out towards HeLa and HCT116 cancer cells.
合成了由咪唑 - 2 - 甲醛和4 - 氨基安替比林衍生的席夫碱的Co(II)、Ni(II)、Cu(II)和Zn(II)配合物。通过元素分析、红外光谱、质谱、(1)H NMR、电子光谱、磁矩、摩尔电导率、热分析、粉末XRD和扫描电子显微镜对这些化合物进行了表征。分析数据表明金属与配体的比例为1:1。红外光谱结果表明配体作为双齿供体通过偶氮甲碱氮和咪唑氮原子配位。根据电子光谱和磁矩值预测配合物的几何结构。通过扫描电子显微镜研究了化合物的表面形态。使用柯氏 - 拜耳纸片扩散法筛选了化合物的抗菌活性和抗真菌活性。研究了化合物的DNA裂解和超氧化物歧化酶活性。对配合物针对HeLa和HCT116癌细胞进行了抗癌活性研究。
