Rodríguez-Violante Mayela, González-Latapi Paulina, Cervantes-Arriaga Amin, Camacho-Ordoñez Azyadeh, Weintraub Daniel
Clinical Laboratory of Neurodegenerative Diseases, National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Movement Disorders Clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
Clinical Laboratory of Neurodegenerative Diseases, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
Parkinsonism Relat Disord. 2014 Aug;20(8):907-10. doi: 10.1016/j.parkreldis.2014.05.014. Epub 2014 Jun 5.
Impulse control disorders (ICDs) are a relatively recent addition to the behavioral spectrum of PD-related non-motor symptoms. Social and economic factors may play a role on the ICD phenotype of PD patients.
The aim of this study is to determine the prevalence and characterize the clinical profile of ICDs in a sample of low-income, low-education PD patients with no social security benefits from a Latin American country.
We included 300 consecutive PD patients and 150 control subjects. The presence of ICD and related disorders was assessed using a structured interview. After the interview and neurological evaluation were concluded, all subjects completed the Questionnaire for Impulsive-compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS).
Regarding ICDs and related disorders (hobbyism-punding), 25.6% (n = 77) of patients in the PD group and 16.6% (n = 25) in the control group fulfilled criteria for at least one ICD or related disorder (p = 0.032). There was a statistically significant difference in the QUIP-RS mean score between PD and control subjects (5.6 ± 9.7 and 2.7 ± 4.21, p = 0.001). The most common ICD was compulsive eating for both PD (8.6%) and control (2.6%) groups.
The results of this study confirm that for this population, symptoms of an ICD are significantly more frequent in PD subjects than in control subjects. Nevertheless, socioeconomic differences may contribute to a lower overall frequency and distinct pattern of ICDs in PD patients compared with what has been reported in other countries.
冲动控制障碍（ICD）是帕金森病（PD）相关非运动症状行为谱中相对较新的一类。社会和经济因素可能对PD患者的ICD表型产生影响。
本研究旨在确定来自拉丁美洲一个国家、无社会保障福利的低收入、低教育水平PD患者样本中ICD的患病率，并描述其临床特征。
我们纳入了300例连续的PD患者和150名对照受试者。使用结构化访谈评估ICD及相关障碍的存在情况。在访谈和神经学评估结束后，所有受试者完成帕金森病冲动控制障碍问卷-评定量表（QUIP-RS）。
关于ICD及相关障碍（嗜好-刻板动作），PD组中25.6%（n = 77）的患者和对照组中16.6%（n = 25）的受试者符合至少一种ICD或相关障碍的标准（p = 0.032）。PD组和对照组在QUIP-RS平均得分上存在统计学显著差异（5.6 ± 9.7和2.7 ± 4.21，p = 0.001）。最常见的ICD在PD组（8.6%）和对照组（2.6%）中均为强迫性进食。
本研究结果证实，对于该人群，PD受试者中ICD症状的发生频率显著高于对照受试者。然而，与其他国家报道的情况相比，社会经济差异可能导致PD患者中ICD的总体发生频率较低且模式不同。
