瞬时受体电位阳离子通道M7（TRPM7）的过表达与人类卵巢癌的不良预后相关。
Overexpression of TRPM7 is associated with poor prognosis in human ovarian carcinoma.
作者信息
Wang Jing, Xiao Ling, Luo Chen-Hui, Zhou Hui, Hu Jun, Tang Yu-Xi, Fang Kai-Ning, Zhang Yi
机构信息
Department of Obstetrics and Gynaecology, Xiangya Hospital, Central South University, Changsha, China E-mail :
出版信息
Asian Pac J Cancer Prev. 2014;15(9):3955-8. doi: 10.7314/apjcp.2014.15.9.3955.
BACKGROUND
The melastatin-related transient receptor potential 7 channel (TRPM7) is a nonselective cation channel that has been shown to promote tumor metastasis and progression. In this study, we determined the expression of TRPM7 in ovarian carcinomas and investigated its possible prognostic value.
MATERIALS AND METHODS
Samples were collected from 138 patients with ovarian cancer. Expression of TRPM7 was assessed by real-time PCR and immunohistochemistry, expressed with reference to an established scoring system and related to clinical pathological factors. Kaplan-Meier survival analysis was applied to estimate disease-free survival (DFS) and overall survival (OS). Univariate and multivariate cox regression analyses were performed to correlate TRPM7 expression levels with DFS and OS.
RESULTS
TRPM7 was highly expressed in ovarian carcinoma and significantly associated with decreased disease-free survival (DFS: median 20 months vs. 42 months, P=0.0002) and overall survival (OS: median 27 months vs. 46 months, P<0.001).
CONCLUSION
Overexpression of TRPM7 expression is significantly associated with poor prognosis in patients with ovarian cancer.
背景
褪黑素相关瞬时受体电位7通道（TRPM7）是一种非选择性阳离子通道，已被证明可促进肿瘤转移和进展。在本研究中，我们测定了TRPM7在卵巢癌中的表达，并探讨了其可能的预后价值。
材料与方法
收集138例卵巢癌患者的样本。通过实时PCR和免疫组织化学评估TRPM7的表达，参照既定评分系统进行表达，并与临床病理因素相关联。应用Kaplan-Meier生存分析来估计无病生存期（DFS）和总生存期（OS）。进行单因素和多因素cox回归分析，以关联TRPM7表达水平与DFS和OS。
结果
TRPM7在卵巢癌中高表达，与无病生存期缩短（DFS：中位数20个月对42个月，P = 0.0002）和总生存期缩短（OS：中位数27个月对46个月，P < 0.001）显著相关。
结论
TRPM7表达的过表达与卵巢癌患者的不良预后显著相关。
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