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钙信号与卵巢癌的潜在治疗靶点（综述）。

Calcium signals and potential therapy targets in ovarian cancer (Review).

机构信息

Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

出版信息

Int J Oncol. 2023 Nov;63(5). doi: 10.3892/ijo.2023.5573. Epub 2023 Sep 15.

DOI:10.3892/ijo.2023.5573
PMID:37711071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10552713/
Abstract

Ovarian cancer (OC) is a deadly disease. The poor prognosis and high lethality of OC are attributed to its high degrees of aggressiveness, resistance to chemotherapy and recurrence rates. Calcium ion (Ca) signaling has received attention in recent years, as it appears to form an essential part of various aspects of cancer pathophysiology and is a potential therapeutic target for OC treatment. Disruption of normal Ca signaling pathways can induce changes in cell cycle progression, apoptosis, proliferation and migration and invasion, leading to the development of the malignant phenotype of tumors. In the present review, the main roles of ion channel/receptor/pump‑triggered Ca signaling pathways located at the plasma membrane and organelle Ca transport in OC are summarized. In addition, the potential of Ca signaling as a novel target for the development of effective treatment strategies for OC was discussed. Furthering the understanding into the role of Ca signaling in OC is expected to facilitated the identification of novel therapeutic targets and improved clinical outcomes for patients.

摘要

卵巢癌（OC）是一种致命的疾病。OC 的预后不良和高致死率归因于其高度侵袭性、对化疗的耐药性和复发率。近年来，钙离子（Ca）信号受到关注，因为它似乎是癌症病理生理学各个方面的重要组成部分，是治疗 OC 的潜在治疗靶点。破坏正常的 Ca 信号通路可诱导细胞周期进程、细胞凋亡、增殖和迁移及侵袭的改变，导致肿瘤恶性表型的发展。在本综述中，总结了位于质膜和细胞器 Ca 转运的离子通道/受体/泵触发的 Ca 信号通路在 OC 中的主要作用。此外，还讨论了 Ca 信号作为开发 OC 有效治疗策略的新靶点的潜力。深入了解 Ca 信号在 OC 中的作用有望促进鉴定新的治疗靶点，并改善患者的临床结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ef1/10552713/3d0434d2dc83/ijo-63-05-05573-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ef1/10552713/dbbe000a36e7/ijo-63-05-05573-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ef1/10552713/b27f5c6d4170/ijo-63-05-05573-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ef1/10552713/3d0434d2dc83/ijo-63-05-05573-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ef1/10552713/dbbe000a36e7/ijo-63-05-05573-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ef1/10552713/b27f5c6d4170/ijo-63-05-05573-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ef1/10552713/3d0434d2dc83/ijo-63-05-05573-g02.jpg

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