微小RNA疗法正在走向成熟。
Development of microRNA therapeutics is coming of age.
作者信息
van Rooij Eva, Kauppinen Sakari
机构信息
Hubrecht Institute, KNAW and University Medical Center, Utrecht, The Netherlands
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark Department of Haematology, Aalborg University Hospital, Aalborg, Denmark
出版信息
EMBO Mol Med. 2014 Jul;6(7):851-64. doi: 10.15252/emmm.201100899.
MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA-based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection.
微小RNA（miRNA）在多种生物过程中发挥关键调节作用，且在人类疾病中常常失调。因此，miRNA已成为一类有前景的治疗干预靶点。在此，我们描述了目前对miRNA进行治疗性调控的策略，并提供了基于miRNA的治疗方法在癌症、心血管疾病和丙型肝炎病毒（HCV）感染治疗方面的进展更新。
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