希腊首次采用全身皮肤电子束（TSEB）疗法治疗蕈样肉芽肿。
First treatment of mycosis fungoides by total skin electron beam (TSEB) therapy in Greece.
作者信息
Diamantopoulos Stefanos, Platoni Kalliopi, Kouloulias Vassilis, Pantelakos Panayiotis, Dilvoi Maria, Papadavid Evangelia, Antoniou Christina, Efstathopoulos Efstathios
机构信息
Radiation Therapy Unit, University General Hospital 'Attikon', Athens, Greece.
Dermatology Department, University General Hospital 'Attikon', Athens, Greece.
出版信息
Rep Pract Oncol Radiother. 2013 Aug 13;19(2):114-9. doi: 10.1016/j.rpor.2013.07.006. eCollection 2014 Mar.
BACKGROUND
Mycosis fungoides (MF), the most common subtype of cutaneous T-Cell Lymphoma (CTCL), is a rare chronic skin neoplasia. Total skin electron irradiation has been employed along with a variety of other topical or systemic treatments for MF management.
AIM
To report the first case treated by TSEB irradiation protocol in Greece.
MATERIALS AND METHODS
A fractionated 36 Gy total skin electron beam (TSEB) therapy was prescribed to a 65-years-old male patient with mycosis fungoides (MF), stage IIB, refractory to several treatments during a 20-year period. Dose uniform delivery was monitored by thermo-luminescence dosimetry.
RESULTS AND DISCUSSION
The homogeneous skin dose distribution resulted in a complete clinical response. Limited, irradiation-oriented, side effects appeared.
CONCLUSIONS
The first TSEB irradiation prescription in Greek medical chronicles was proved effective in this case of tumor stage MF (T3-IIB), which had been refractory to several single or combination treatments.
背景
蕈样肉芽肿（MF）是皮肤T细胞淋巴瘤（CTCL）最常见的亚型，是一种罕见的慢性皮肤肿瘤。全身皮肤电子线照射已与多种其他局部或全身治疗方法一起用于MF的治疗。
目的
报告希腊首例采用全身皮肤电子束照射（TSEB）方案治疗的病例。
材料与方法
为一名65岁的蕈样肉芽肿（MF）IIB期男性患者制定了36 Gy的分次全身皮肤电子束（TSEB）治疗方案，该患者在20年期间对多种治疗均无效。通过热释光剂量测定法监测剂量均匀输送。
结果与讨论
均匀的皮肤剂量分布导致了完全的临床反应。出现了有限的、以照射为导向的副作用。
结论
希腊医学编年史中的首例TSEB照射处方在该例肿瘤分期为MF（T3-IIB）且对多种单一或联合治疗均无效的病例中被证明是有效的。
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