原发性甲状旁腺功能亢进患者甲状旁腺切除术前及术后血清单核细胞趋化蛋白-1水平
Serum monocyte chemokine protein-1 levels before and after parathyroidectomy in patients with primary hyperparathyroidism.
作者信息
Patel Hemal, Trooskin Stanley, Shapses Sue, Sun Wei, Wang Xiangbing
机构信息
Division of Endocrinology, Rutgers Robert Wood Johnson Medical School.
Division of General Surgery, Departments of Medicine and Surgery, Rutgers Robert Wood Johnson Medical School.
出版信息
Endocr Pract. 2014 Nov;20(11):1165-9. doi: 10.4158/EP14104.OR.
OBJECTIVE
To investigate the effects of parathyroidectomy on serum monocyte chemokine protein-1 (MCP-1) levels in patients with primary hyperparathyroidism (PHPT).
METHODS
Forty-three PHPT patients, age 56 ± 12 years, underwent minimally invasive parathyroidectomy. Serum samples were collected at 0 and 15 to 20 minutes after parathyroid adenoma removal. Serum samples were stored at -70°C until time of assay.
RESULTS
In 40 PHPT patients with a single adenoma, MCP-1 levels decreased from 342 ± 103 to 250 ± 77 pg/mL (P<.001) 15 to 20 minutes after parathyroid adenoma removal. MCP-1 levels were positively correlated with intact parathyroid hormone (PTH) levels (R = 0.47; P<.01). In 3 PHPT patients with double parathyroid adenoma, MCP-1 levels did not decrease after removal of the first adenoma but decreased 15 to 20 minutes after second adenoma removal.
CONCLUSION
Our results provide evidence that the decrease in serum intact PTH due to minimally invasive parathyroidectomy results in an immediate decrease in serum MCP-1 levels.
目的
探讨甲状旁腺切除术对原发性甲状旁腺功能亢进症（PHPT）患者血清单核细胞趋化蛋白-1（MCP-1）水平的影响。
方法
43例年龄为56±12岁的PHPT患者接受了微创甲状旁腺切除术。在切除甲状旁腺腺瘤后0分钟以及15至20分钟采集血清样本。血清样本储存于-70°C直至检测时。
结果
在40例患有单个腺瘤的PHPT患者中，切除甲状旁腺腺瘤后15至20分钟，MCP-1水平从342±103 pg/mL降至250±77 pg/mL（P<.001）。MCP-1水平与完整甲状旁腺激素（PTH）水平呈正相关（R = 0.47；P<.01）。在3例患有双发性甲状旁腺腺瘤的PHPT患者中，切除第一个腺瘤后MCP-1水平未降低，但在切除第二个腺瘤后15至20分钟降低。
结论
我们的结果提供了证据，即微创甲状旁腺切除术导致血清完整PTH降低，进而使血清MCP-1水平立即降低。
Zotero 插件