The Netherlands Cancer Institute, Division of Cell Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
The Netherlands Cancer Institute, Division of Cell Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Curr Biol. 2014 Jun 16;24(12):R571-R573. doi: 10.1016/j.cub.2014.05.009.
Chromosomal instability is a driving force for heterogeneity within tumours. A recent study shows that boosting sister chromatid cohesion corrects chromosomal instability in pRB-deficient cancer cells. This key finding provides an important lead to make tumours more susceptible to anti-cancer drugs.
染色体不稳定是肿瘤内部异质性的驱动力。最近的一项研究表明，增强姐妹染色单体黏合可纠正 pRB 缺陷型癌细胞中的染色体不稳定。这一关键发现为提高肿瘤对癌症药物的敏感性提供了重要线索。
