MDS 毕竟是一种干细胞疾病。

MDS is a stem cell disorder after all.

机构信息

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Cancer Cell. 2014 Jun 16;25(6):713-4. doi: 10.1016/j.ccr.2014.06.001.

DOI:10.1016/j.ccr.2014.06.001

PMID:24937455

Abstract

Myelodysplastic syndrome (MDS) has long been presumed to be a stem cell disorder, but rigorous formal proof has been lacking. In this issue of Cancer Cell, Woll and colleagues demonstrate that driver mutations occurring in MDS definitively occur in cells with a stem cell phenotype.

摘要

骨髓增生异常综合征（MDS）长期以来一直被认为是一种干细胞疾病，但一直缺乏严格的正式证据。在本期《癌细胞》杂志中，Woll 及其同事证明，MDS 中发生的驱动突变确实发生在具有干细胞表型的细胞中。