胶质细胞破坏癌症干细胞分化的机制。
Gremlins sabotage the mechanisms of cancer stem cell differentiation.
机构信息
Vall d Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, 08035 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain; Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain.
出版信息
Cancer Cell. 2014 Jun 16;25(6):716-7. doi: 10.1016/j.ccr.2014.06.002.
PMID:24937457
Abstract
BMP is highly expressed in glioblastoma and promotes differentiation of cancer stem cells (CSCs). Recently, Yan and colleagues found the explanation to this apparent paradox by showing that the antagonist of BMP, Gremlin1, is secreted by CSCs to protect them against the BMP-induced differentiation.
摘要
BMP 在胶质母细胞瘤中高度表达，并促进癌症干细胞（CSC）的分化。最近，Yan 及其同事通过研究发现，BMP 的拮抗剂 Gremlin1 由 CSC 分泌，以保护它们免受 BMP 诱导的分化，从而解释了这一明显的悖论。
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