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[内镜胎儿手术]

[Endocopic fetal surgery].

作者信息

Cruz-Martínez Rogelio, Gratacos Eduard

出版信息

Ginecol Obstet Mex. 2014 May;82(5):325-36.

PMID:24937948
Abstract

At present, the fetus is already considered a "patient" and as such, can develop diseases with fatal outcome in which the only therapeutic option can be fetal surgery. Currently, fetal surgery is limited almost exclusively to endoscopic surgery. Different techniques have gained clinical acceptance for improving the prognosis of various lethal fetal pathologies. Laser therapy for twin to twin transfusion syndrome and cord occlusion in monochorionic twins with selective intrauterine growth restriction are the procedures of choice for the management of monochorionic twins complications, and are associated with survival rates of up to 80-90% for at least one fetus. In fetuses with isolated congenital diaphragmatic hernia and severe pulmonary hypoplasia, fetal endoscopic tracheal occlusion has shown to improve the survival probabilities from 5% to 55% and from 1% to 33% in left and right congenital diaphragmatic hernia, respectively, and a decrease in the rate of pulmonary hypertension and neonatal morbidity. In selected cases with low urinary tract obstruction (megacystis) and without renal failure; fetal cystoscopy is a diagnostic method that excludes the possibility of urethral stenosis or atresia and may be used to ablate posterior urethral valves by laser, restoring urethral patency and potentially preserving respiratory and bladder function. In fetuses with pulmonary masses, either primary or due to airway obstruction, there is high risk of fetal death due to cardiac compression and contralateral pulmonary hypoplasia. In such cases fetal bronchoscopy can provide a successful therapeutic option to release airway obstruction.

摘要

目前,胎儿已被视为“患者”,因此可能患上导致致命后果的疾病,而唯一的治疗选择可能是胎儿手术。目前,胎儿手术几乎仅限于内镜手术。不同的技术已获得临床认可,用于改善各种致命性胎儿疾病的预后。激光治疗双胎输血综合征以及对选择性宫内生长受限的单绒毛膜双胎进行脐带闭塞,是处理单绒毛膜双胎并发症的首选方法,至少有一个胎儿的存活率可达80% - 90%。对于孤立性先天性膈疝且伴有严重肺发育不全的胎儿,胎儿内镜气管闭塞已显示可将左侧和右侧先天性膈疝的存活率分别从5%提高到55%以及从1%提高到33%,并降低肺动脉高压和新生儿发病率。在选定的下尿路梗阻(巨大膀胱)且无肾衰竭的病例中,胎儿膀胱镜检查是一种诊断方法,可排除尿道狭窄或闭锁的可能性,还可用于通过激光消融后尿道瓣膜,恢复尿道通畅,并有可能保留呼吸和膀胱功能。对于患有肺部肿块(无论是原发性还是由于气道阻塞)的胎儿,由于心脏受压和对侧肺发育不全,存在较高的胎儿死亡风险。在这种情况下,胎儿支气管镜检查可为解除气道阻塞提供成功的治疗选择。

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[Endocopic fetal surgery].[内镜胎儿手术]
Ginecol Obstet Mex. 2014 May;82(5):325-36.
2
Fetal hydrops after in utero tracheal occlusion.
J Pediatr Surg. 1997 Feb;32(2):214-5; discussion 216. doi: 10.1016/s0022-3468(97)90181-0.
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Palliative fetal surgery for diaphragmatic hernia.胎儿膈疝的姑息性手术
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Fetal surgery for lung lesions, congenital diaphragmatic hernia, and sacrococcygeal teratoma.针对肺部病变、先天性膈疝和骶尾部畸胎瘤的胎儿手术。
Semin Pediatr Surg. 2003 Aug;12(3):154-67. doi: 10.1016/s1055-8586(03)00030-1.
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Fetoscopic surgery: encouraged by clinical experience and boosted by instrument innovation.胎儿镜手术:受临床经验鼓舞并因器械创新而得到推动。
Semin Fetal Neonatal Med. 2006 Dec;11(6):398-412. doi: 10.1016/j.siny.2006.09.003. Epub 2006 Oct 20.
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Fetendo-clip: a fetal endoscopic tracheal clip procedure in a human fetus.胎儿气管夹闭术:人类胎儿的胎儿内镜下气管夹闭手术
J Pediatr Surg. 1997 Jul;32(7):970-2. doi: 10.1016/s0022-3468(97)90379-1.
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Fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia: indications, outcomes, and future directions.胎儿内镜下气管闭塞术治疗先天性膈疝:适应证、结局及未来方向
Obstet Gynecol Surv. 2014 Mar;69(3):147-58. doi: 10.1097/OGX.0000000000000045.
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A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia.胎儿内镜下气管闭塞治疗严重胎儿先天性膈疝的随机试验。
N Engl J Med. 2003 Nov 13;349(20):1916-24. doi: 10.1056/NEJMoa035005.
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Fetal pulmonary response after fetoscopic tracheal occlusion for severe isolated congenital diaphragmatic hernia.胎儿镜下气管阻塞术治疗严重先天性膈疝的胎儿肺脏反应。
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[Fetal surgery: for selected patients. The experiences of the Fetal Treatment Center in San Francisco].[胎儿手术:针对特定患者。旧金山胎儿治疗中心的经验]
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