Dhillon J, Mitchison D A
Department of Bacteriology, Royal Postgraduate Medical School, London,UK.
Br J Exp Pathol. 1989 Feb;70(1):103-10.
The influence of previous BCG vaccination on the bactericidal activity of isoniazid and rifampicin has been studied using serial counts of viable tubercle bacilli in the spleens and lungs of mice and guinea-pigs infected intravenously with M. tuberculosis, strain H37Rv. In mice, BCG vaccination decreased the bactericidal activity of isoniazid in the spleen, but did not affect its activity in the lungs, where immunity is less strongly expressed. BCG did not influence the bactericidal activity of rifampicin in either organ. In contrast, previous BCG vaccination in the guinea-pig increased the bactericidal activity of isoniazid and rifampicin in the spleen and lungs. The differences between the animal species might result from the immune response being mainly bacteriostatic in the mouse but bactericidal in the guinea-pig.
利用静脉注射结核分枝杆菌H37Rv株感染的小鼠和豚鼠脾脏及肺中活结核杆菌的连续计数，研究了先前卡介苗接种对异烟肼和利福平杀菌活性的影响。在小鼠中，卡介苗接种降低了异烟肼在脾脏中的杀菌活性，但不影响其在肺部的活性，因为肺部的免疫表达较弱。卡介苗对利福平在任一器官中的杀菌活性均无影响。相比之下，先前在豚鼠中接种卡介苗可提高异烟肼和利福平在脾脏和肺部的杀菌活性。动物物种之间的差异可能是由于免疫反应在小鼠中主要是抑菌性的，而在豚鼠中是杀菌性的。
