Goldberg Mark S, Wheeler Amanda J, Burnett Richard T, Mayo Nancy E, Valois Marie-France, Brophy James M, Giannetti Nadia
1] Department of Medicine, McGill University, Montreal, Quebec, Canada [2] Division of Clinical Epidemiology, Department of Medicine, Research Institute, McGill University Health Centre, Montreal, Quebec, Canada.
1] Centre for Ecosystem Management, School of Natural Sciences, Edith Cowan University, Perth, Western Australia, Australia [2] Air Health Science Division, Health Canada, Ottawa, Ontario, Canada.
J Expo Sci Environ Epidemiol. 2015 Mar-Apr;25(2):187-99. doi: 10.1038/jes.2014.43. Epub 2014 Jun 18.
We carried out this daily diary panel study in Montreal, Quebec, to determine whether oxygen saturation, pulse rate, blood pressure, self-rated health, and shortness of breath at night were associated with concentrations of indoor carbon monoxide (CO), and indoor and outdoor fine particles (PM2.5), temperature, and relative humidity. Over a 2-month consecutive period between 2008 and 2010, we measured daily indoor and outdoor levels of the air pollutants and weather variables and 55 subjects measured their daily health and other variables. To estimate the associations between the health outcomes and the environmental exposures, we used a mixed effects regression model using an autoregressive model of order-one and we adjusted for month and day and personal variables. The general pattern of associations can be summarized as follows: oxygen saturation was reduced for increases in indoor- and outdoor-PM2.5 and temperature. Pulse rate increased on the concurrent day for increases in indoor CO and PM2.5. Diastolic blood pressure increased with increasing indoor and outdoor PM2.5 and relative humidity. Systolic blood pressure increased with indoor PM2.5 and decreased with increasing indoor and outdoor temperature. Self-rated health diminished with increases in outdoor PM2.5 and indoor and outdoor temperature. Self-reported shortness of breath at night increased with increasing indoor and outdoor temperatures. Health in heart failure is affected in the short term by personal and environmental conditions that are manifest in intermediate physiological parameters.
我们在魁北克省蒙特利尔市开展了这项日常日记小组研究，以确定血氧饱和度、脉搏率、血压、自我评定健康状况以及夜间呼吸急促是否与室内一氧化碳（CO）浓度、室内和室外细颗粒物（PM2.5）、温度及相对湿度相关。在2008年至2010年连续的2个月期间，我们每日测量室内和室外空气污染物水平及天气变量，55名受试者则测量其每日健康状况及其他变量。为估计健康结果与环境暴露之间的关联，我们使用了一个混合效应回归模型，该模型采用一阶自回归模型，并对月份、日期及个人变量进行了调整。关联的总体模式可总结如下：室内和室外PM2.5及温度升高会导致血氧饱和度降低。室内CO和PM2.5增加会使当日脉搏率上升。舒张压随室内和室外PM2.5及相对湿度升高而升高。收缩压随室内PM2.5升高而升高，随室内和室外温度升高而降低。自我评定健康状况随室外PM2.5及室内和室外温度升高而下降。自我报告的夜间呼吸急促随室内和室外温度升高而增加。心力衰竭患者的健康在短期内会受到个人和环境状况的影响，这些状况会在中间生理参数中体现出来。
