Sayd Salwa, Junier Marie-Pierre, Chneiweiss Hervé
Équipe plasticité gliale, Neuroscience Paris Seine, CNRS U8246, Inserm U1130, université Pierre et Marie Curie, 7 quai Saint Bernard, 75005 Paris, France - Laboratoire de génétique et pathologie moléculaire, faculté de médecine et de pharmacie de Casablanca, Maroc.
Équipe plasticité gliale, Neuroscience Paris Seine, CNRS U8246, Inserm U1130, université Pierre et Marie Curie, 7 quai Saint Bernard, 75005 Paris, France.
Med Sci (Paris). 2014 May;30(5):532-6. doi: 10.1051/medsci/20143005016. Epub 2014 Jun 13.
Sirtuin 2 (SIRT2) is an NAD(+) (nicotinamide adenine dinucleotide)-dependent deacetylase. Studies of this protein have often been divergent, highlighting the dependence of pleiotropic effects of SIRT2 on cellular context. The natural polyphenol resveratrol is known to exert opposite actions on neural cells according to their normal or cancerous status. We have recently shown the involvement of SIRT2 in the antiproliferative effects of resveratrol on primary cultures of human glioblastoma stem cells. SIRT2 could become a new therapeutic target.
沉默调节蛋白2（SIRT2）是一种依赖烟酰胺腺嘌呤二核苷酸（NAD(+)）的去乙酰化酶。对这种蛋白质的研究结果常常存在分歧，这突出了SIRT2多效性作用对细胞环境的依赖性。已知天然多酚白藜芦醇根据神经细胞的正常或癌变状态对其产生相反的作用。我们最近发现SIRT2参与了白藜芦醇对人胶质母细胞瘤干细胞原代培养物的抗增殖作用。SIRT2可能成为一个新的治疗靶点。
