Xianghong G, Guanping C, Fenghua Y, Jiayin W
Center Department of Clinical Laboratory Medicine, Linyi People's Hospital, Linyi 276003, China.
Afr Health Sci. 2013 Dec;13(4):1079-83. doi: 10.4314/ahs.v13i4.31.
Hepatic impairment, portal hypertension, and multi-systemic damage could occur during liver cirrhosis's late stage. Bleeding is a complication of hepatic cirrhosis along with several changes including blood platelet count (BPC), mean platelet volume (MPV), platelet crit (PCT) and expression of platelet CD62P. Blood platelet count (BPC), mean platelet volume (MPV), platelet distribution width, and other indices are indirect reflections of CD62P parameters.
To investigate the changes in platelet functional parameters and CD62 P expression in liver cirrhosis as a possible guide in clinical treatments and prognoses of liver cirrhosis.
CD62P was tested by flow cytometry in liver cirrhosis. BPC, MPV, and PCT in peripheral blood were tested using an auto blood cell analyzer. Data were analyzed using SPSS11.0.
The values of CD62P and MPV in patients was significantly higher than those of healthy donors (P<0.01), while the values of BPC and PCT were significantly lower than those of the control group (P<0.01).
CD62P, BPC, MPV, and platelet crit (PCT) show several changes in liver cirrhosis. It is useful to understand the relationship between hepatic cirrhosis severity and CD62P, BPC, MPV, PCT, timely monitoring of CD62P for treatment of hepatic cirrhosis in clinical treatment and prognosis.
肝硬化晚期可出现肝功能损害、门静脉高压及多系统损害。出血是肝硬化的一种并发症，伴有包括血小板计数（BPC）、平均血小板体积（MPV）、血小板压积（PCT）及血小板CD62P表达等多项变化。血小板计数（BPC）、平均血小板体积（MPV）、血小板分布宽度等指标是CD62P参数的间接反映。
探讨肝硬化患者血小板功能参数及CD62P表达的变化，为肝硬化的临床治疗及预后提供可能的指导。
采用流式细胞术检测肝硬化患者的CD62P。使用自动血细胞分析仪检测外周血中的BPC、MPV和PCT。数据采用SPSS11.0进行分析。
患者的CD62P和MPV值显著高于健康供者（P<0.01），而BPC和PCT值显著低于对照组（P<0.01）。
CD62P、BPC、MPV和血小板压积（PCT）在肝硬化中呈现多项变化。了解肝硬化严重程度与CD62P、BPC、MPV、PCT之间的关系，在临床治疗和预后中及时监测CD62P对肝硬化的治疗具有重要意义。
