Tervo T, Tervo K, van Setten G B, Virtanen I, Tarkkanen A
Department of Ophthalmology, University of Helsinki, Finland.
Exp Eye Res. 1989 Mar;48(3):445-9. doi: 10.1016/s0014-4835(89)80012-0.
Anterior keratectomy was performed to 10 eyes of 8 adult rabbits. The animals were killed 3-24 hr after wound closure. The corneas were excised and subjected to histochemical demonstration of urokinase-type plasminogen activator (u-PA), tissue-type PA (t-PA) and plasminogen activator inhibitor [PAI-1) using commercial antibodies. A strong immunoreaction for u-PA, a weaker reaction for PAI-1 and a very weak t-PA-like immunoreaction appeared in the anterior stroma of the wounded area. None of the antisera used showed any immunostaining in the cornea outside the wound. The role of the plasminogen activator-plasmin system in the healing of the corneal wound is discussed.
