Oka Yoko, Tashiro Haruko, Sirasaki Ryosuke, Yamamoto Tadashi, Akiyama Nobu, Kawasugi Kazuo, Shirafuji Naoki, Fujimori Shin
a Department of Internal Medicine , Teikyo University, School of Medicine , Kaga Itabashiku , Tokyo , Japan.
Nucleosides Nucleotides Nucleic Acids. 2014;33(4-6):434-8. doi: 10.1080/15257770.2013.872274.
In order to elucidate the mechanism of hyperuricemia in hematologic malignancies, we have retrospectively investigated the uric acid metabolism in 418 chemotherapy-naïve patients with hematologic malignancies. Hyperuricemia was present in 116 (27.8%) of these patients on initial hospitalization. Among 65 hyperuricemic patients analyzed uric acid metabolism, six (9.2%) had overproduction type, 52 (80.0%) had underexcretion type, and seven (10.8%) had a mixed type. Fourteen patients (3.3%) developed tumor lysis syndrome in 418 patients.
为了阐明血液系统恶性肿瘤患者高尿酸血症的机制，我们回顾性研究了418例初治血液系统恶性肿瘤患者的尿酸代谢情况。这些患者初次住院时，116例（27.8%）存在高尿酸血症。在分析尿酸代谢的65例高尿酸血症患者中，6例（9.2%）为尿酸生成过多型，52例（80.0%）为排泄减少型，7例（10.8%）为混合型。418例患者中有14例（3.3%）发生了肿瘤溶解综合征。
