Comparative genomics of Mycobacterium tuberculosis drug efflux pumps and their transcriptional regulators.
作者信息
Liu Hong, Xie Jianping
机构信息
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, Southwest University.
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Enviroment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing, China.
出版信息
Crit Rev Eukaryot Gene Expr. 2014;24(2):163-80. doi: 10.1615/critreveukaryotgeneexpr.2014007826.
Efflux pump systems are important in general drug resistance. Understanding efflux pumps can inform drug target selection and novel antibiotics designs. In this review, we have summarized the physiological roles, types, and mechanisms of drug efflux pumps. Mycobacterium tuberculosis is the causative agent of tuberculosis, a global threat to public health, and the increasing resistance of this mycobacterium to antibiotics is alarming. Therefore, we have focused on the comparative genomics of efflux pumps and relevant transcriptional regulators of M. tuberculosis.
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