Chowdhury Mohammed Andaleeb, Derar Nada, Hasan Syed, Hinch Bryan, Ratnam Shoba, Assaly Ragheb
Department of Internal Medicine, University of Toledo, Toledo, OH.
Am J Ther. 2016 May-Jun;23(3):e941-3. doi: 10.1097/MJT.0000000000000093.
Neurotoxicity can develop as a side effect of intravenous acyclovir use in patients with renal impairment. It is underreported in clinical practice and often confused with worsening herpes encephalitis. We present a 69-year-old woman with end-stage renal disease on hemodialysis with acyclovir neurotoxicity treated with daily extended hemodialysis sessions. Daily hemodialysis for extended period may shorten the neurotoxicity period and can help with faster return to normal mentation. A high index of suspicion is warranted to diagnose acyclovir-induced neurotoxicity.
神经毒性可能作为肾功能损害患者静脉使用阿昔洛韦的副作用而出现。在临床实践中其报告不足，且常与疱疹性脑炎病情恶化相混淆。我们报告一名69岁终末期肾病接受血液透析的女性，其因阿昔洛韦神经毒性接受每日延长血液透析治疗。长时间每日血液透析可能缩短神经毒性期，并有助于更快恢复正常精神状态。诊断阿昔洛韦诱导的神经毒性需要高度怀疑。
