Abuhelwa Ziad, Beran Azizullah, Venkataramany Barat S, Hinch Bryan T, Assaly Ragheb
Department of Medicine, University of Toledo, Toledo, USA.
Cureus. 2022 Mar 31;14(3):e23693. doi: 10.7759/cureus.23693. eCollection 2022 Mar.
Drug-induced nephrotoxicity and neurotoxicity are commonly encountered problems in clinical practice. We describe a case of concurrent valacyclovir-induced nephrotoxicity and neurotoxicity in a 64-year-old man with no history of renal disease who developed acute renal injury and neurological symptoms after he received two weeks of the standard dose of oral valacyclovir for herpes zoster meningitis. His clinical condition improved significantly after the initiation of hemodialysis. Although nephrotoxicity due to intravenous infusion of valacyclovir and/or acyclovir is not uncommon, oral valacyclovir therapy is rarely associated with nephrotoxicity in patients with no history of renal insufficiency. Additionally, concurrent nephrotoxicity and neurotoxicity due to valacyclovir and/or acyclovir are rarely reported. Clinicians should be aware of these adverse events as immediate recognition and intervention are necessary to prevent morbidity.
药物性肾毒性和神经毒性是临床实践中常见的问题。我们描述了一例64岁男性同时发生的伐昔洛韦诱导的肾毒性和神经毒性病例，该患者无肾脏疾病史，在接受为期两周的标准剂量口服伐昔洛韦治疗带状疱疹脑膜炎后出现急性肾损伤和神经症状。开始血液透析后，他的临床状况显著改善。虽然静脉输注伐昔洛韦和/或阿昔洛韦引起的肾毒性并不少见，但口服伐昔洛韦治疗在无肾功能不全病史的患者中很少与肾毒性相关。此外，很少有关于伐昔洛韦和/或阿昔洛韦同时引起肾毒性和神经毒性的报道。临床医生应意识到这些不良事件，因为立即识别和干预对于预防发病是必要的。
