A Hg(II)-mediated "signal-on" electrochemical glutathione sensor.
作者信息
Lotfi Zadeh Zhad Hamid R, Lai Rebecca Y
机构信息
Department of Chemistry, Hamilton Hall, University of Nebraska-Lincoln, Lincoln, NE 68588-0304, USA.
出版信息
Chem Commun (Camb). 2014 Aug 7;50(61):8385-7. doi: 10.1039/c4cc03329a.
PMID:24942852
Abstract
We report the design and fabrication of a DNA-based electrochemical sensor for detection of glutathione. Sensor signaling relies on glutathione's ability to chelate mercury Hg(II), displacing it from the thymine-Hg(II)-thymine complex formed between the surface-immobilized DNA probes. Our results show that this sensor is sensitive and selective enough to be employed in saliva.
摘要
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