Almeida M S, Pinto R M, Noronha D, Katz N, Tendler M
Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
J Parasitol. 1989 Apr;75(2):308-10.
New Zealand rabbits were infected on day 1 and challenged on days 15, 30, and 60 with 1,000 Schistosoma mansoni cercariae/animal/infection. Challenged and control rabbits were perfused 60 days after each infection, corresponding to days 75, 90, and 120 after the first exposure. No decrease in number of adult schistosomes occurred in animals reinfected 15 days after primary infection, but, when the rabbits were challenged 30 and 60 days after the first infection, worm burden reduction of 61.4% and 92.6%, respectively, was observed as compared to infection controls. These data indicate that rabbits submitted to reinfection are able to kill the worms from their primary infection, besides being protected against challenge parasites.
新西兰兔在第1天感染，在第15、30和60天分别用1000条曼氏血吸虫尾蚴/动物/感染进行攻击。每次感染后60天对攻击组和对照组兔子进行灌注，这分别对应于首次暴露后第75、90和120天。初次感染后15天再次感染的动物中，成虫数量没有减少，但是，当兔子在首次感染后30天和60天受到攻击时，与感染对照组相比，虫负荷分别降低了61.4%和92.6%。这些数据表明，再次感染的兔子除了能抵御攻击寄生虫外，还能够杀死初次感染的蠕虫。
