Bousman Chad A, Sarris Jerome, Won Eun-Soo, Chang Hun-Soo, Singh Ajeet, Lee Hwa-Young, Ham Byung-Joo, Tan Chay-Hoon, Lee Min-Soo, Ng Chee H
From the *Department of Psychiatry, The University of Melbourne, Parkville; †Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne; ‡Florey Institute for Neuroscience and Mental Health, Parkville; and §Department of General Practice, The University of Melbourne, Melbourne, Australia; ∥Department of Psychiatry, College of Medicine, Korea University, Seoul; and ¶Department of Medical Bioscience, Graduate School, Soonchunhyang University, Bucheon, Republic of Korea; #School of Medicine, Deakin University, Geelong, Australia; **Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Cheonan City, Republic of Korea; and ††Department of Pharmacology, National University of Singapore, Singapore, Singapore.
J Clin Psychopharmacol. 2014 Oct;34(5):645-8. doi: 10.1097/JCP.0000000000000165.
Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.
目前的证据表明，血清素转运体基因（5-HTTLPR）的多态性可预测白人对抗抑郁药物的疗效，但对亚洲人的预测性较差。然而，尚不清楚这种效应是否能在特定类型的抗抑郁药物中观察到。47名白人及118名韩国的重度抑郁症患者接受了依他普仑治疗，并在8周内进行评估。在那些具有l/l而非l/s或s/s基因型的患者中，与韩国人相比，白人的抑郁评分降低幅度更大，缓解率和治愈率更高。我们的结果表明，5-HTTLPR以种族依赖的方式预测依他普仑的疗效。
