内侧前额叶皮质前边缘区的深部脑刺激：使用[18F]FDG微型正电子发射断层扫描定量分析对大鼠脑葡萄糖代谢的影响
Deep brain stimulation of the prelimbic medial prefrontal cortex: quantification of the effect on glucose metabolism in the rat brain using [(18) F]FDG microPET.
作者信息
Parthoens Joke, Verhaeghe Jeroen, Stroobants Sigrid, Staelens Steven
机构信息
Molecular Imaging Center Antwerp (MICA), University of Antwerp, Universiteitsplein 1, Wilrijk, Antwerp, 2610, Belgium.
出版信息
Mol Imaging Biol. 2014 Dec;16(6):838-45. doi: 10.1007/s11307-014-0757-9.
PURPOSE
Prefrontal cortex (PFC) deep brain stimulation (DBS) has been proposed as a therapy for addiction and depression. This study investigates changes in rat cerebral glucose metabolism induced by different DBS frequencies using μPET.
PROCEDURES
One hour DBS of the prelimbic area (PL) of the medial PFC (mPFC) (60 Hz, 130 Hz or sham) in rats (n = 9) was followed by 2-deoxy-2-[(18) F] fluoro-D-glucose ([(18) F]FDG) μPET.
RESULTS
Sixty Hz DBS elicited significant hypermetabolism in the ipsilateral PL ([(18) F]FDG uptake +5.2 ± 2.3 %, p < 0.05). At 130 Hz, hypometabolism was induced in the ipsilateral PL (-2.5 ± 2.6 %, non-significant). Statistical parametric mapping revealed hypo and hypermetabolism clusters for both 60 and 130 Hz versus sham and show a certain state of alertness (increased activity in sensory and motor-related regions) mainly for 60 Hz.
CONCLUSIONS
This study suggests the potential of 60 Hz PL mPFC DBS for the treatment of disorders associated with prefrontal hypofunction.
目的
前额叶皮质（PFC）深部脑刺激（DBS）已被提议作为成瘾和抑郁症的一种治疗方法。本研究使用μPET研究不同DBS频率诱导的大鼠脑葡萄糖代谢变化。
程序
对大鼠（n = 9）内侧前额叶皮质（mPFC）的前边缘区（PL）进行1小时的DBS（60赫兹、130赫兹或假刺激），随后进行2-脱氧-2-[(18)F]氟-D-葡萄糖（[(18)F]FDG）μPET检查。
结果
60赫兹的DBS引起同侧PL显著的代谢亢进（[(18)F]FDG摄取量增加5.2±2.3%，p < 0.05）。在130赫兹时，同侧PL诱导出现代谢减退（-2.5±2.6%，无统计学意义）。统计参数映射显示，与假刺激相比，60赫兹和130赫兹均有代谢减退和亢进簇，并且主要在60赫兹时显示出一定的警觉状态（感觉和运动相关区域的活动增加）。
结论
本研究表明60赫兹PL mPFC DBS在治疗与前额叶功能减退相关疾病方面具有潜力。
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