Nayyar Abhishek Singh, Khan Mubeen, Bafna U D, Siddique Ahmed, Gayitri H C
Department of Oral Medicine and Radiology, Government Dental College and Research Institute, Bangalore, Karnataka, India.
Indian J Pathol Microbiol. 2014 Apr-Jun;57(2):223-30. doi: 10.4103/0377-4929.134672.
The diagnosis of malignant and potentially malignant epithelial lesions of the oral mucosa cannot be based solely on clinical findings. The histologic evaluation of a representative biopsy specimen thus becomes necessary. The site for biopsy however is always a subjective choice that sometimes raises doubts about its representativeness. So far, no simple and reliable method is available for the selection of the most appropriate area for biopsy. Colposcopy is helpful in the selection of these sites of epithelial dysplasia depending upon the vascular patterns.
This study was planned to assess the role of Colposcopic examination in the selection of biopsy site in patients with varying grades of oral epithelial dysplasia at various sites.
One hundred and eighty patients between the ages of 30 and 60 years clinically diagnosed with leukoplakia and carcinoma buccal mucosa were included in the study.
For each of the subjects, a thorough clinical examination followed by Colposcopic assessment was carried out for the selection of biopsy site from the involved mucosa. The histopathological findings were then compared in the two cases and results analyzed.
The statistical analysis was performed using a paired t-test.
In our study, sensitivity and specificity for the selection of biopsy site by Colposcopic examination was found to be higher for leukoplakia than for carcinoma buccal mucosa.
It was concluded that Colposcopic examination was found to be significant in the selection of biopsy site for leukoplakia while clinical criterion was found to be more appropriate for carcinoma buccal mucosa cases.
口腔黏膜恶性及潜在恶性上皮病变的诊断不能仅基于临床检查结果。因此，对代表性活检标本进行组织学评估就变得必要。然而，活检部位始终是一个主观选择，有时会让人对其代表性产生怀疑。到目前为止，尚无简单可靠的方法来选择最合适的活检区域。阴道镜检查有助于根据血管形态选择这些上皮发育异常的部位。
本研究旨在评估阴道镜检查在不同部位不同分级的口腔上皮发育异常患者活检部位选择中的作用。
本研究纳入了180例年龄在30至60岁之间、临床诊断为白斑和颊黏膜癌的患者。
对每个受试者进行全面的临床检查，随后进行阴道镜评估，以从受累黏膜中选择活检部位。然后比较两种情况下的组织病理学结果并分析结果。
采用配对t检验进行统计分析。
在我们的研究中，发现阴道镜检查选择活检部位对白斑的敏感性和特异性高于颊黏膜癌。
得出的结论是，阴道镜检查在白斑活检部位的选择中具有重要意义，而临床标准在颊黏膜癌病例中更为合适。
