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Novel activators of aquaporin 2 membrane expression for the treatment of nephrogenic diabetes insipidus: less is more. Focus on "High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration".

作者信息

Sands Jeff M, Blount Mitsi A

机构信息

Renal Division, Department of Medicine, and Department of Physiology, Emory University School of Medicine, Atlanta, Georgia

Renal Division, Department of Medicine, and Department of Physiology, Emory University School of Medicine, Atlanta, Georgia.

出版信息

Am J Physiol Cell Physiol. 2014 Oct 1;307(7):C595-6. doi: 10.1152/ajpcell.00184.2014. Epub 2014 Jun 18.

DOI:10.1152/ajpcell.00184.2014
PMID:24944199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4187059/
Abstract
摘要

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Am J Physiol Cell Physiol. 2014 Oct 1;307(7):C597-605. doi: 10.1152/ajpcell.00154.2014. Epub 2014 Jun 18.

本文引用的文献

1
High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration.高通量化学筛选鉴定出 AG-490 是水通道蛋白 2 膜表达和尿液浓缩的刺激剂。
Am J Physiol Cell Physiol. 2014 Oct 1;307(7):C597-605. doi: 10.1152/ajpcell.00154.2014. Epub 2014 Jun 18.
2
The physiological and pathophysiological functions of renal and extrarenal vasopressin V2 receptors.肾脏和肾外血管加压素 V2 受体的生理和病理生理功能。
Am J Physiol Renal Physiol. 2014 May 1;306(9):F931-40. doi: 10.1152/ajprenal.00604.2013. Epub 2014 Mar 5.
3
Sildenafil reduces polyuria in rats with lithium-induced NDI.西地那非可减少锂诱导的 NDI 大鼠的多尿。
Am J Physiol Renal Physiol. 2012 Jan 1;302(1):F216-25. doi: 10.1152/ajprenal.00439.2010. Epub 2011 Oct 26.
4
Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase.辛伐他汀通过调节 Rho GTPase 增强血管加压素缺乏性 Brattleboro 大鼠水通道蛋白-2 的表面表达和尿液浓缩。
Am J Physiol Renal Physiol. 2011 Aug;301(2):F309-18. doi: 10.1152/ajprenal.00001.2011. Epub 2011 Apr 20.
5
Calcitonin has a vasopressin-like effect on aquaporin-2 trafficking and urinary concentration.降钙素对水通道蛋白-2的运输和尿液浓缩具有类似血管加压素的作用。
J Am Soc Nephrol. 2011 Jan;22(1):59-72. doi: 10.1681/ASN.2009121267. Epub 2010 Nov 11.
6
A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus.一种选择性 EP4 PGE2 受体激动剂可缓解新型 X 连锁性肾性尿崩症小鼠模型的疾病。
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