Novel activators of aquaporin 2 membrane expression for the treatment of nephrogenic diabetes insipidus: less is more. Focus on "High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration".
作者信息
Sands Jeff M, Blount Mitsi A
机构信息
Renal Division, Department of Medicine, and Department of Physiology, Emory University School of Medicine, Atlanta, Georgia
Renal Division, Department of Medicine, and Department of Physiology, Emory University School of Medicine, Atlanta, Georgia.
出版信息
Am J Physiol Cell Physiol. 2014 Oct 1;307(7):C595-6. doi: 10.1152/ajpcell.00184.2014. Epub 2014 Jun 18.
Abstract
摘要
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Novel activators of aquaporin 2 membrane expression for the treatment of nephrogenic diabetes insipidus: less is more. Focus on "High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration".用于治疗肾性尿崩症的水通道蛋白2膜表达的新型激活剂：少即是多。聚焦于“高通量化学筛选鉴定出AG-490作为水通道蛋白2膜表达和尿液浓缩的刺激剂”。
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High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration.高通量化学筛选鉴定出 AG-490 是水通道蛋白 2 膜表达和尿液浓缩的刺激剂。
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2
The physiological and pathophysiological functions of renal and extrarenal vasopressin V2 receptors.肾脏和肾外血管加压素 V2 受体的生理和病理生理功能。
Am J Physiol Renal Physiol. 2014 May 1;306(9):F931-40. doi: 10.1152/ajprenal.00604.2013. Epub 2014 Mar 5.
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Sildenafil reduces polyuria in rats with lithium-induced NDI.西地那非可减少锂诱导的 NDI 大鼠的多尿。
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