Wei Yong-Bao, Yan Bin, Yin Zhuo, Yang Jin-Rui
Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Exp Ther Med. 2014 Jul;8(1):91-94. doi: 10.3892/etm.2014.1725. Epub 2014 May 20.
Eosinophilia is typically associated with allergic reactions, parasitic infestations, certain forms of vasculitis, the use of certain medications and hematologic malignancies. In addition to eosinophilia associated with gastrointestinal tumors, lung cancer and thyroid carcinoma in solid malignancies, there are a limited number of cases describing peripheral hypereosinophilia in urologic tumors. The present study reports three cases of eosinophilia in patients with chromophobe renal cell carcinoma (CRCC) and investigates the association between excessive eosinophilia and the recurrence and prognosis of renal carcinoma. This is the first report of CRCC associated with excessive eosinophilia. Eosinophilia following tumor resectioning may indicate a poor prognosis, tumor recurrence and rapid disease progression.
嗜酸性粒细胞增多通常与过敏反应、寄生虫感染、某些形式的血管炎、某些药物的使用以及血液系统恶性肿瘤有关。除了实体恶性肿瘤中与胃肠道肿瘤、肺癌和甲状腺癌相关的嗜酸性粒细胞增多外，描述泌尿系统肿瘤外周嗜酸性粒细胞增多的病例数量有限。本研究报告了3例嫌色肾细胞癌（CRCC）患者出现嗜酸性粒细胞增多的情况，并探讨了嗜酸性粒细胞过度增多与肾癌复发及预后之间的关系。这是关于CRCC与嗜酸性粒细胞过度增多相关的首例报告。肿瘤切除后出现嗜酸性粒细胞增多可能预示预后不良、肿瘤复发及疾病快速进展。
