Int J Psychiatry Clin Pract. 2002;6(3):179-81. doi: 10.1080/136515002760276135.
A patient was receiving treatment for concurrent opioid and stimulant dependency. When desipramine was added to his lofexidine regimen for treatment of stimulant withdrawal, there was an exacerbation of opioid withdrawal symptoms. With the increasing use of lofexidine for opioid withdrawal, clinicians need to be aware of the potential for interactions with tricyclic antidepressants in the treatment of concomitant stimulant users. (Int J Psych Clin Pract 2002; 6: 179-181 ).
一位患者同时患有阿片类药物和兴奋剂依赖，正在接受治疗。当用去甲替林来治疗兴奋剂戒断时，他的可乐定治疗方案加剧了阿片类药物戒断症状。随着可乐定在阿片类药物戒断中的应用越来越多，临床医生需要意识到在治疗同时使用兴奋剂的患者时，与三环类抗抑郁药相互作用的可能性。（Int J Psych Clin Pract 2002; 6: 179-181）。
