Li J, Menzies D, Landry J S, Benedetti A, Rousseau M C
INRS-Institut Armand-Frappier, Université du Québec, 531 des Prairies, Laval, Québec H7V 1B7, Canada; Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, 1020 Pine Avenue West, Montréal, Québec H3A 1A2, Canada.
Montreal Chest Institute, McGill University Health Centre, 3650 St-Urbain, Montréal, Québec H2Z 2P4, Canada; Respiratory Epidemiology and Clinical Research Unit (RECRU), McGill University, 3650 St-Urbain, Montréal, Québec H2Z 2P4, Canada; Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, 1020 Pine Avenue West, Montréal, Québec H3A 1A2, Canada.
Prev Med. 2014 Sep;66:87-94. doi: 10.1016/j.ypmed.2014.06.012. Epub 2014 Jun 16.
To identify determinants of Bacillus Calmette-Guérin (BCG) vaccination among children born in Québec, Canada, in 1974, the last year of the systematic vaccination campaign.
A retrospective birth cohort was assembled in 2011 through probabilistic linkage of administrative databases (n=81,496). Potential determinants were documented from administrative databases and by interviewing a subset of subjects (n=1643) in 2012. Analyses were conducted among subjects with complete data, 71,658 (88%) birth cohort subjects and 1154 (70%) interviewed subjects, then redone using multiple imputation. Determinants of BCG vaccination during the organized vaccination program (in 1974), and after the program (1975 onwards) were assessed separately. Logistic regression with backward elimination was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
Overall, 46% of subjects were BCG vaccinated, 43% during the program and 4% after it ended. BCG vaccination during the program was associated with parents' birthplace and urban or rural residence. BCG vaccination after the organized program was only related to ethnocultural origin of the child's grandparents.
Different factors were related to vaccination within and after the organized program. Determinants of BCG vaccination in Québec, Canada, have never been studied and will be useful for future research and vaccination campaigns.
确定1974年在加拿大魁北克省出生的儿童中卡介苗（BCG）接种的决定因素，这是系统性疫苗接种运动的最后一年。
2011年通过行政数据库的概率链接组建了一个回顾性出生队列（n = 81,496）。潜在的决定因素通过行政数据库记录，并在2012年对一部分受试者（n = 1643）进行访谈。对有完整数据的受试者进行分析，包括71,658名（88%）出生队列受试者和1154名（70%）接受访谈的受试者，然后使用多重填补法重新进行分析。分别评估了有组织疫苗接种计划期间（1974年）和计划之后（1975年及以后）卡介苗接种的决定因素。采用向后逐步回归的逻辑回归来估计比值比（OR）和95%置信区间（CI）。
总体而言，46%的受试者接种了卡介苗，43%在计划期间接种，4%在计划结束后接种。计划期间的卡介苗接种与父母的出生地以及城乡居住情况有关。有组织计划结束后的卡介苗接种仅与孩子祖父母的种族文化背景有关。
有组织计划期间和之后的疫苗接种相关因素不同。加拿大魁北克省卡介苗接种的决定因素从未被研究过，这将对未来的研究和疫苗接种运动有所帮助。
