细胞病毒受体和附着因子相关基因中的单核苷酸多态性与风疹疫苗体液免疫之间的关联。
Associations between single nucleotide polymorphisms in cellular viral receptors and attachment factor-related genes and humoral immunity to rubella vaccination.
作者信息
Haralambieva Iana H, Lambert Nathaniel D, Ovsyannikova Inna G, Kennedy Richard B, Larrabee Beth R, Pankratz V Shane, Poland Gregory A
机构信息
Mayo Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, United States of America; Program in Translational Immunovirology and Biodefense, Mayo Clinic, Rochester, Minnesota, United States of America.
Division of Biostatistics, Mayo Clinic, Rochester, Minnesota, United States of America.
出版信息
PLoS One. 2014 Jun 19;9(6):e99997. doi: 10.1371/journal.pone.0099997. eCollection 2014.
BACKGROUND
Viral attachment and cell entry host factors are important for viral replication, pathogenesis, and the generation and sustenance of immune responses after infection and/or vaccination, and are plausible genetic regulators of vaccine-induced immunity.
METHODS
Using a tag-SNP approach in candidate gene study, we assessed the role of selected cell surface receptor genes, attachment factor-related genes, along with other immune genes in the genetic control of immune response variations after live rubella vaccination in two independent study cohorts.
RESULTS
Our analysis revealed evidence for multiple associations between genetic variants in the PVR, PVRL2, CD209/DC-SIGN, RARB, MOG, IL6 and other immune function-related genes and rubella-specific neutralizing antibodies after vaccination (meta p-value <0.05).
CONCLUSION
Our results indicate that multiple SNPs from genes involved in cell adhesion, viral attachment, and viral entry, as well as others in genes involved in signaling and/or immune response regulation, play a role in modulating humoral immune responses following live rubella vaccination.
背景
病毒附着和细胞进入宿主因子对于病毒复制、发病机制以及感染和/或接种疫苗后免疫反应的产生和维持非常重要，并且可能是疫苗诱导免疫的遗传调节因子。
方法
在候选基因研究中使用标签单核苷酸多态性方法，我们在两个独立的研究队列中评估了选定的细胞表面受体基因、附着因子相关基因以及其他免疫基因在风疹活疫苗接种后免疫反应变异的遗传控制中的作用。
结果
我们的分析揭示了PVR、PVRL2、CD209/DC-SIGN、RARB、MOG、IL6和其他免疫功能相关基因中的遗传变异与接种后风疹特异性中和抗体之间存在多种关联的证据（荟萃p值<0.05）。
结论
我们的结果表明，参与细胞粘附、病毒附着和病毒进入的基因以及参与信号传导和/或免疫反应调节的其他基因中的多个单核苷酸多态性在调节风疹活疫苗接种后的体液免疫反应中发挥作用。
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