Wei Hongmin, Yang Jinjuan, Zhang Hanqi, Shi Yuhua
College of Chemistry, Jilin University, Changchun, P.R. China.
J Sep Sci. 2014 Sep;37(17):2349-56. doi: 10.1002/jssc.201400313. Epub 2014 Jul 14.
A simple, rapid, and efficient method of ultrasonic nebulization extraction assisted dispersive liquid-liquid microextraction was developed for the simultaneous determination of six parabens in cosmetic products. The analysis was carried out by gas chromatography. Water was used as the dispersive solvent instead of traditional organic disperser. The experimental factors affecting the extraction yield, such as the extraction solvent and volume, extraction time, dispersive solvent and volume, ionic strength, and centrifuging condition were studied and optimized in detail. The limit of detections for the target analytes were in the range of 2.0-9.5 μg/g. Good linear ranges were obtained with the coefficients ranging from 0.9934 to 0.9969. The proposed method was successfully applied to the analysis of six parabens in 16 cosmetic products. The recoveries of the target analytes in real samples ranged from 81.9 to 108.7%, and the relative standard deviations were <5.3%.
建立了一种简单、快速、高效的超声雾化萃取辅助分散液液微萃取方法，用于同时测定化妆品中的六种对羟基苯甲酸酯。采用气相色谱法进行分析。用水代替传统的有机分散剂作为分散溶剂。详细研究并优化了影响萃取率的实验因素，如萃取溶剂及体积、萃取时间、分散溶剂及体积、离子强度和离心条件等。目标分析物的检测限在2.0 - 9.5μg/g范围内。获得了良好的线性范围，系数在0.9934至0.9969之间。该方法成功应用于16种化妆品中六种对羟基苯甲酸酯的分析。实际样品中目标分析物的回收率在81.9%至108.7%之间，相对标准偏差<5.3%。
