Sadr-Eshkevari Pooyan, Ashnagar Sajjad, Rashad Ashkan, Dietz Marisa, Jackowski Jochen, Abdulazim Amr, Prochnow Nora
School of Dentistry, University of California , Los Angeles, CA , USA.
Cell Commun Adhes. 2014 Oct;21(5):241-7. doi: 10.3109/15419061.2014.927869. Epub 2014 Jun 19.
Bisphosphonates (BPs) are drugs commonly used in the treatment of various disease arising or affecting bone tissue. There is a standard use in bone neoplasia and metastasis, hormonal and developmental disorders as well as for compensation of adverse effects in several medical therapies. Many in-vivo and in-vitro studies have assessed the efficacy of this drug and its function in cellular scale. In this concern, BPs are described to inhibit the resorptive function of osteoclasts and to prevent apoptosis of osteoblasts and osteocytes. They can preserve the osteocytic network, reduce fracture rate, and increase the bone mineral content, which is therapeutically used. Connexin 43 (Cx43) is a crucial molecule for basal regulation of bone homeostasis, development, and differentiation. It is described for signal transduction in many physiological and pathological stimuli and recently to be involved in BP action.
双膦酸盐（BPs）是常用于治疗各种起源于或影响骨组织的疾病的药物。在骨肿瘤和转移、激素及发育障碍以及几种医学治疗中不良反应的补偿方面有标准用法。许多体内和体外研究评估了这种药物的疗效及其在细胞水平的功能。在这方面，双膦酸盐被描述为可抑制破骨细胞的吸收功能，并防止成骨细胞和骨细胞凋亡。它们可以维持骨细胞网络，降低骨折率，并增加骨矿物质含量，这些都具有治疗用途。连接蛋白43（Cx43）是骨稳态、发育和分化基础调节的关键分子。它在许多生理和病理刺激的信号转导中发挥作用，最近还被发现参与双膦酸盐的作用。
