Effect of valproate on lactate and glutamine metabolism by rat renal cortical tubules. - Suppr | 超能文献

Effect of valproate on lactate and glutamine metabolism by rat renal cortical tubules.

作者信息

Doval M, Culebras M, Lopez-Farré A, Rengel M, Gougoux A, Vinay P, Lopez-Novoa J M

机构信息

Laboratory of Renal Physiopathology-CSIC, Fundacion Jiménez Diaz, Madrid, Spain.

出版信息

Proc Soc Exp Biol Med. 1989 Apr;190(4):357-64. doi: 10.3181/00379727-190-42872.

DOI:10.3181/00379727-190-42872

Abstract

The metabolic effects of sodium valproate (VPA) on rat renal cortical tubules have been examined. When 1 or 5 mM lactate was used as substrate in the incubation medium, VPA decreased markedly the lactate uptake by the tubules. When 1 or 5 mM glutamine was used, the addition of VPA accelerated glutamine uptake, ammoniagenesis, but also stimulated markedly the accumulation of lactate and pyruvate produced from glutamine. VPA had a dose-dependent inhibitory effect on gluconeogenesis from both glutamine and lactate. With 5 mM glutamine, VPA also induced a significant accumulation of glutamate in the medium. The oxygen consumption by the tubules was diminished by 40% following VPA addition. It is concluded that VPA modifies the metabolism of rat cortical tubules by interfering with the oxidation of natural substrates and stimulates in this fashion the production of ammonia by kidney tubules.

摘要

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