保乳根治性乳房切除术后乳腺癌复发：单机构经验
Breast cancer recurrence after nipple-sparing mastectomy: one institution's experience.
作者信息
Poruk Katherine E, Ying Jian, Chidester Jeremy R, Olson Joshua R, Matsen Cindy B, Neumayer Leigh, Agarwal Jayant
机构信息
Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA.
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
出版信息
Am J Surg. 2015 Jan;209(1):212-7. doi: 10.1016/j.amjsurg.2014.04.001. Epub 2014 May 4.
BACKGROUND
Nipple-sparing mastectomy (NSM) has been increasingly used to treat women with breast cancer who wish to preserve the overlying breast skin, but concern remains regarding tumor recurrence. We report our experience performing NSM for breast cancer treatment and prophylaxis over a 6-year period.
METHODS
A retrospective chart review on patients undergoing NSM or skin-sparing mastectomy (SSM) from 2005 to 2011 was performed.
RESULTS
NSM patients were younger (P < .001), had a lower body mass index (P < .001), and were associated with a family cancer risk (P = .01) but not genetic risk (P = .83). There was no difference in the distance between the tumor and the nipple-areola complex when comparing NSM and SSM (P = .47). There was no significant difference in recurrence (P = .08) or survival (P = .38) when comparing NSM and SSM after controlling for age, stage, and surgery laterality.
CONCLUSIONS
There was no difference in survival or cancer recurrence for NSM or SSM. NSM does not increase the risk of recurrence or decrease survival.
背景
保留乳头的乳房切除术（NSM）越来越多地用于治疗希望保留乳房皮肤的乳腺癌女性患者，但对于肿瘤复发仍存在担忧。我们报告了我们在6年期间进行NSM治疗乳腺癌及预防性手术的经验。
方法
对2005年至2011年期间接受NSM或保留皮肤的乳房切除术（SSM）的患者进行回顾性病历审查。
结果
NSM患者更年轻（P <.001），体重指数更低（P <.001），且与家族癌症风险相关（P =.01），但与遗传风险无关（P =.83）。比较NSM和SSM时，肿瘤与乳头乳晕复合体之间的距离无差异（P =.47）。在控制年龄、分期和手术侧别后，比较NSM和SSM时，复发率（P =.08）或生存率（P =.38）无显著差异。
结论
NSM和SSM在生存率或癌症复发方面无差异。NSM不会增加复发风险或降低生存率。
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