Center for Discovery and Innovation in Parasitic Diseases, University of California, San Francisco, California, USA.
Center for Discovery and Innovation in Parasitic Diseases, University of California, San Francisco, California, USA.
Trends Parasitol. 2014 Jul;30(7):342-9. doi: 10.1016/j.pt.2014.05.001. Epub 2014 Jun 16.
Trypanosomatid parasites infect over 21 million people worldwide, with a range of disease phenotypes. Trypanosoma cruzi causes American trypanosomiasis, wherein 30-40% of infected individuals develop disease manifestations, most commonly cardiomyopathy but also digestive megasyndromes. In the case of Trypanosoma brucei, the etiological agent of African trypanosomiasis, disease progression can be rapid or slow, with early or late central nervous system involvement. Finally, Leishmania species cause leishmaniasis, a disease that ranges from self-healing but scarring cutaneous lesions to fatal visceral leishmaniasis in which parasites disseminate to the liver, spleen, and bone marrow. This review highlights parasite factors involved in disease phenotype in all three trypanosomatid diseases, with a particular focus on recent advances using large-scale 'omics' techniques.
锥虫类寄生虫感染全球超过 2100 万人，表现出多种疾病表型。克氏锥虫引起美洲锥虫病，其中 30-40%的感染者出现疾病表现，最常见的是心肌病，但也有消化系统巨症候群。在布氏锥虫引起的非洲锥虫病的情况下，疾病的进展可以是快速的或缓慢的，早期或晚期涉及中枢神经系统。最后，利什曼原虫引起利什曼病，这种疾病的范围从自我愈合但留下疤痕的皮肤损伤到致命的内脏利什曼病，其中寄生虫扩散到肝脏、脾脏和骨髓。这篇综述强调了在所有三种锥虫病中与疾病表型相关的寄生虫因素，特别关注了使用大规模“组学”技术的最新进展。
