Department of Medicine, Division of Infectious Diseases, University of Connecticut Health Center, Farmington, Connecticut.
Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut.
J Am Acad Dermatol. 2014 Jul;71(1):11.e1-7; quiz 18-20. doi: 10.1016/j.jaad.2014.01.879.
Tumor necrosis factor-alfa levels are linked to disease severity in patients with inflammatory conditions, such as psoriasis. Inhibitors of this cytokine are commonly used with significant success in the treatment of such inflammatory disorders. Their use, however, can be plagued by infectious complications. An awareness of potential infections associated with these therapies is critical in order to maximize preventive efforts both before and during therapy. This review provides a guide for dermatologists caring for patients in need of this type of biologic therapy to preemptively address the infectious risks. Part II of this continuing medical education article reviews recommended screening methods for patients undergoing evaluations for tumor necrosis factor inhibitor therapy for psoriasis or other dermatologic diseases, and discusses possible prophylactic strategies to use, including the appropriate use of immunizations.
肿瘤坏死因子-α 水平与炎症性疾病患者的疾病严重程度相关，例如银屑病。这种细胞因子的抑制剂常用于治疗此类炎症性疾病，并取得了显著的成功。然而，其使用可能会受到感染并发症的困扰。了解这些治疗方法相关的潜在感染至关重要，以便在治疗前后最大限度地预防感染。本综述为需要这种生物治疗的患者提供了皮肤科医生的指导，以预先解决感染风险。本继续教育文章的第二部分回顾了接受肿瘤坏死因子抑制剂治疗银屑病或其他皮肤病的患者的推荐筛查方法，并讨论了可能的预防策略，包括免疫接种的合理使用。
