Woo Jean, Leung Jason, Morley John E
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.
The Jockey Club Centre for Osteoporosis Care and Control, The Chinese University of Hong Kong, Hong Kong.
J Am Med Dir Assoc. 2014 Sep;15(9):630-4. doi: 10.1016/j.jamda.2014.04.021. Epub 2014 Jun 16.
Using data from the Hong Kong Mr and Ms Os study, we validated the SARC-F against 3 consensus definitions of sarcopenia from Europe, Asia, and an international group, and compared the ability of all 4 measures to predict 4-year physical limitation, walking speed, and repeated chair stands.
Prospective cohort study.
Hong Kong community.
Four thousand men and women living in the community.
A questionnaire regarding ability to carry a heavy load, walking, rising from a chair, climbing stairs, and falls frequency was administered. These questions were used to calculate the SARC-F score. Measurements, including appendicular muscle mass, were taken using dual-energy X-ray, grip strength using a dynamometer, 6-m gait speed, and time taken for repeated chair stand. Classification using the SARC-F score was compared using consensus panel criteria from international, European, and Asian sarcopenia working groups. The performance of all 4 methods was compared by examining the predictive ability for 4-year outcomes using ROC curve.
The SARC-F has excellent specificity but poor sensitivity for sarcopenia classification; however, all 4 methods have comparable but modest predictive power for 4-year physical limitation.
The SARC-F may be considered a suitable tool for community screening for sarcopenia.
利用香港“老年先生和女士”研究的数据，我们对照欧洲、亚洲及一个国际组织的3种肌少症共识定义对SARC - F进行了验证，并比较了这4种测量方法预测4年身体功能受限、步行速度和重复起坐能力的能力。
前瞻性队列研究。
香港社区。
居住在社区的4000名男性和女性。
发放了一份关于搬运重物、行走、从椅子上起身、爬楼梯及跌倒频率能力的问卷。这些问题用于计算SARC - F评分。采用双能X线测量包括四肢肌肉量在内的指标，用握力计测量握力，测量6米步速及重复起坐所需时间。使用国际、欧洲和亚洲肌少症工作组的共识小组标准比较基于SARC - F评分的分类情况。通过用ROC曲线检验4年结局的预测能力来比较所有4种方法的性能。
SARC - F对肌少症分类具有出色的特异性，但敏感性较差；然而，所有4种方法对4年身体功能受限具有相当但适度的预测能力。
SARC - F可被视为社区肌少症筛查的合适工具。
