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验证SARC-F:一种适用于肌少症的社区筛查工具?

Validating the SARC-F: a suitable community screening tool for sarcopenia?

作者信息

Woo Jean, Leung Jason, Morley John E

机构信息

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.

The Jockey Club Centre for Osteoporosis Care and Control, The Chinese University of Hong Kong, Hong Kong.

出版信息

J Am Med Dir Assoc. 2014 Sep;15(9):630-4. doi: 10.1016/j.jamda.2014.04.021. Epub 2014 Jun 16.

Abstract

OBJECTIVES

Using data from the Hong Kong Mr and Ms Os study, we validated the SARC-F against 3 consensus definitions of sarcopenia from Europe, Asia, and an international group, and compared the ability of all 4 measures to predict 4-year physical limitation, walking speed, and repeated chair stands.

DESIGN

Prospective cohort study.

SETTING

Hong Kong community.

PARTICIPANTS

Four thousand men and women living in the community.

MEASUREMENTS

A questionnaire regarding ability to carry a heavy load, walking, rising from a chair, climbing stairs, and falls frequency was administered. These questions were used to calculate the SARC-F score. Measurements, including appendicular muscle mass, were taken using dual-energy X-ray, grip strength using a dynamometer, 6-m gait speed, and time taken for repeated chair stand. Classification using the SARC-F score was compared using consensus panel criteria from international, European, and Asian sarcopenia working groups. The performance of all 4 methods was compared by examining the predictive ability for 4-year outcomes using ROC curve.

RESULTS

The SARC-F has excellent specificity but poor sensitivity for sarcopenia classification; however, all 4 methods have comparable but modest predictive power for 4-year physical limitation.

CONCLUSION

The SARC-F may be considered a suitable tool for community screening for sarcopenia.

摘要

目的

利用香港“老年先生和女士”研究的数据,我们对照欧洲、亚洲及一个国际组织的3种肌少症共识定义对SARC - F进行了验证,并比较了这4种测量方法预测4年身体功能受限、步行速度和重复起坐能力的能力。

设计

前瞻性队列研究。

地点

香港社区。

参与者

居住在社区的4000名男性和女性。

测量

发放了一份关于搬运重物、行走、从椅子上起身、爬楼梯及跌倒频率能力的问卷。这些问题用于计算SARC - F评分。采用双能X线测量包括四肢肌肉量在内的指标,用握力计测量握力,测量6米步速及重复起坐所需时间。使用国际、欧洲和亚洲肌少症工作组的共识小组标准比较基于SARC - F评分的分类情况。通过用ROC曲线检验4年结局的预测能力来比较所有4种方法的性能。

结果

SARC - F对肌少症分类具有出色的特异性,但敏感性较差;然而,所有4种方法对4年身体功能受限具有相当但适度的预测能力。

结论

SARC - F可被视为社区肌少症筛查的合适工具。

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