生物素化探针的合理设计：（链）霉抗生物素蛋白的荧光开启检测及癌细胞中的生物成像
Rational design of biotinylated probes: fluorescent turn-on detection of (strept)avidin and bioimaging in cancer cells.
作者信息
Sun Qian, Qian Junhong, Tian Haiyu, Duan Liping, Zhang Weibing
机构信息
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China.
出版信息
Chem Commun (Camb). 2014 Aug 11;50(62):8518-21. doi: 10.1039/c4cc03315a.
PMID:24948217
Abstract
Two fluorescent probes SPS1 and SPS2 were designed by connecting biotin to an environment-sensitive coumarin fluorophore. Streptavidin and avidin induced dramatical fluorescence changes in both probes. SPS2 has potential in fluorescent imaging of biotin receptor-enriched tumor cells.
摘要
通过将生物素连接到对环境敏感的香豆素荧光团上，设计了两种荧光探针SPS1和SPS2。链霉亲和素和抗生物素蛋白在这两种探针中均引起显著的荧光变化。SPS2在富含生物素受体的肿瘤细胞的荧光成像方面具有潜力。
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