Sun Qian, Qian Junhong, Tian Haiyu, Duan Liping, Zhang Weibing
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Chem Commun (Camb). 2014 Aug 11;50(62):8518-21. doi: 10.1039/c4cc03315a.
Two fluorescent probes SPS1 and SPS2 were designed by connecting biotin to an environment-sensitive coumarin fluorophore. Streptavidin and avidin induced dramatical fluorescence changes in both probes. SPS2 has potential in fluorescent imaging of biotin receptor-enriched tumor cells.
通过将生物素连接到对环境敏感的香豆素荧光团上，设计了两种荧光探针SPS1和SPS2。链霉亲和素和抗生物素蛋白在这两种探针中均引起显著的荧光变化。SPS2在富含生物素受体的肿瘤细胞的荧光成像方面具有潜力。
