通过4.7T磁共振成像对大鼠缺血模型的脑血容量进行研究。
Cerebral blood volume in a rat model of ischemia by MR imaging at 4.7 T.
作者信息
Kent T A, Quast M J, Kaplan B J, Najafi A, Amparo E G, Gevedon R M, Salinas F, Suttle A D, DiPette D J, Eisenberg H M
机构信息
Department of Neurology, University of Texas Medical Branch, Galveston 77550.
出版信息
AJNR Am J Neuroradiol. 1989 Mar-Apr;10(2):335-8.
Perturbation of the cerebral circulation by occlusion of the vertebral arteries and a carotid artery can be visualized by using MR imaging and the intravascular contrast agent Gd-DTPA complexed to albumin. This tracer consistently reduced the T1 relaxation time in the brain and blood. The difference between hemispheres was revealed by less T1 reduction in the occluded hemisphere and by an adjustment in the display contrast of images that revealed the territory of decreased perfusion. These results were confirmed by comparing them with cerebral blood flow using radioactive microspheres and the intravascular blood volume tracer 51Cr-EDTA. This method, combined with high-resolution MR imaging, can be applied to serial noninvasive studies of cerebral blood volume in ischemia and other conditions.
通过使用磁共振成像（MR成像）以及与白蛋白复合的血管内造影剂钆-二乙三胺五乙酸（Gd-DTPA），可以观察到椎动脉和一条颈动脉闭塞对脑循环的干扰。这种示踪剂持续缩短了脑和血液中的T1弛豫时间。通过闭塞半球T1缩短较少以及调整显示灌注减少区域的图像的显示对比度，揭示了半球之间的差异。通过将这些结果与使用放射性微球和血管内血容量示踪剂51铬-乙二胺四乙酸（51Cr-EDTA）测量的脑血流量进行比较，证实了这些结果。这种方法与高分辨率MR成像相结合，可应用于对缺血及其他情况时脑血容量的系列无创研究。
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